枯草芽孢杆菌嘧啶生物合成的遗传学与生物化学：导致尿嘧啶需求的突变之间的联系
Genetics and biochemistry of pyrimidine biosynthesis in Bacillus subtilis: linkage between mutations resulting in a requirement for uracil.
作者信息
Kelleher R J, Gooder H
出版信息
J Bacteriol. 1973 Nov;116(2):577-81. doi: 10.1128/jb.116.2.577-581.1973.
Abstract
A number of independently derived uracil-requiring mutant strains of the parent strain 168 were mapped by inter-mutant transformation crosses. Only a few of these mutant strains were found to be transformable. Studies were performed in which these transformable uracil-requiring mutant strains were used as the recipient of deoxyribonucleic acid extracted from phenotypically similar mutant strains. The results yielded data resulting in a fine-structure map in which all mutations were found to be linked in a small region corresponding to that previously published as the uracil region of the Bacillus subtilis genome.
摘要
通过突变体间转化杂交对亲本菌株168的多个独立衍生的尿嘧啶需求突变菌株进行了定位。发现这些突变菌株中只有少数是可转化的。进行了一些研究，其中将这些可转化的尿嘧啶需求突变菌株用作从表型相似的突变菌株中提取的脱氧核糖核酸的受体。结果产生的数据形成了一个精细结构图谱，其中所有突变都被发现在一个小区域内连锁，该区域对应于先前发表的枯草芽孢杆菌基因组的尿嘧啶区域。
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