枯草芽孢杆菌中亮氨酸生物合成的遗传学研究。
Genetic studies of leucine biosynthesis in Bacillus subtilis.
作者信息
Ward J B, Zahler S A
出版信息
J Bacteriol. 1973 Nov;116(2):719-26. doi: 10.1128/jb.116.2.719-726.1973.
Abstract
The mutations in a series of leucine auxotrophs isolated after treatment with nitrosoguanidine, ultraviolet light, and ICR-191 have been mapped between ilvC and pheA on the Bacillus subtilis chromosome. A fine structure map of the region was constructed by transformation. Analysis of several strains by assaying levels of their leucine bioysnthetic enzymes has shown that the region encodes three enzymes. The order of the genes with respect to the biosynthetic steps catalyzed by the gene products is 1-3-2.
摘要
在用亚硝基胍、紫外线和ICR - 191处理后分离出的一系列亮氨酸营养缺陷型菌株中的突变，已定位在枯草芽孢杆菌染色体上的ilvC和pheA之间。通过转化构建了该区域的精细结构图。通过测定几种菌株的亮氨酸生物合成酶水平进行分析，结果表明该区域编码三种酶。就基因产物催化的生物合成步骤而言，基因顺序为1 - 3 - 2。
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