Mora J O, de Paredes B, Wagner M, de Navarro L, Suescun J, Christiansen N, Herrera M G
Am J Clin Nutr. 1979 Feb;32(2):455-62. doi: 10.1093/ajcn/32.2.455.
Colombian women at risk of malnutrition were enrolled in a health care program and randomly assigned to supplementation and control groups at the beginning of the third trimester of pregnancy. The net dietary intake increments resulting from supplementation amounted to 155 cal and 20 g of protein per day. Supplementation had a significant effect on the mean birth weight of male infants, but not that of female infants; the mechanisms responsible for the sex differences remain to be elucidated. The randomized trial design of the experiment and the documented similarity between the experimental and control groups at the onset permit the conclusion that the observed differences were caused by the food supplementation program. The effect of supplementation on maternal weight gain and the association of the latter with birth weight strongly suggest that improved maternal nutrition mediated the effect on birth weight.
有营养不良风险的哥伦比亚女性被纳入一个医疗保健项目，并在妊娠晚期开始时随机分为补充组和对照组。补充剂导致的每日净膳食摄入量增加为155卡路里和20克蛋白质。补充剂对男婴的平均出生体重有显著影响，但对女婴没有；造成性别差异的机制仍有待阐明。该实验的随机试验设计以及实验开始时实验组和对照组之间记录的相似性使得可以得出结论，观察到的差异是由食物补充项目引起的。补充剂对母亲体重增加的影响以及后者与出生体重的关联强烈表明，改善的母亲营养介导了对出生体重的影响。
