颈动脉结扎对狒狒脑血流量的影响。I. 对动脉血二氧化碳分压改变的反应。
Effect of carotid ligation on cerebral blood flow in baboons. I. Response to altered arterial PCO2.
作者信息
Sengupta D, Harper M, Jennett B
出版信息
J Neurol Neurosurg Psychiatry. 1973 Oct;36(5):736-41. doi: 10.1136/jnnp.36.5.736.
Measurements of cerebral blood flow (CBF) were made in anaesthetized baboons before and after ipsilateral carotid artery ligation and also after bilateral carotid ligation. Results showed that at normocapnia (PaCO(2) 38-39 mmHg) there was little change in cerebral blood flow on ipsilateral carotid ligation, but when both carotid arteries were tied the blood flow to the brain fell significantly. At hypercapnia (PaCO(2) 58-60 mmHg) the CBF/CO(2) gradient fell significantly on ipsilateral carotid ligation; on bilateral carotid ligation there was only minimal rise in cerebral blood flow in response to the rise in PaCO(2). At hypocapnia (PaCO(2) 20-21 mmHg) the gradients of fall in the CBF were similar before and after ipsilateral carotid ligation; after bilateral carotid ligation there was minimal change in the CBF in response to the fall in the PaCO(2). It is suggested that, although cerebral blood flow may be normal after ipsilateral carotid ligation, the circulatory reserve of the brain is not sufficient to meet physiological challenges. This may be the reason for the development of delayed neurological complications after carotid artery ligation.
在同侧颈动脉结扎前后以及双侧颈动脉结扎后，对麻醉的狒狒进行脑血流量（CBF）测量。结果显示，在正常碳酸血症（动脉血二氧化碳分压[PaCO₂] 38 - 39 mmHg）时，同侧颈动脉结扎后脑血流量变化不大，但双侧颈动脉结扎后，脑血流量显著下降。在高碳酸血症（PaCO₂ 58 - 60 mmHg）时，同侧颈动脉结扎后CBF/CO₂梯度显著下降；双侧颈动脉结扎后，随着PaCO₂升高，脑血流量仅略有增加。在低碳酸血症（PaCO₂ 20 - 21 mmHg）时，同侧颈动脉结扎前后CBF下降的梯度相似；双侧颈动脉结扎后，随着PaCO₂下降，CBF变化极小。研究表明，尽管同侧颈动脉结扎后脑血流量可能正常，但大脑的循环储备不足以应对生理挑战。这可能是颈动脉结扎后出现延迟性神经并发症的原因。
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