Wyper D J, Lennox G A, Rowan J O
J Neurol Neurosurg Psychiatry. 1976 Feb;39(2):147-51. doi: 10.1136/jnnp.39.2.147.
The two minute slope technique for measuring CBF was devised primarily to study the response of the cerebral circulation to physiological stimuli. In this paper, measurements of the precision of the technique when applied to various groups of people are described, and measurements on normal subjects of the global and regional CBF changes in response to hyperventilation and hypercapnia are presented. It is shown that CBF measured using this technique during percutaneous carotid compression may prove useful in the prediction of cerebral ischaemia in patients who are candidates for carotid ligation.
用于测量脑血流量（CBF）的两分钟斜率技术主要是为研究脑循环对生理刺激的反应而设计的。本文描述了该技术应用于不同人群时的精度测量，并给出了正常受试者在过度通气和高碳酸血症时全脑和局部脑血流量变化的测量结果。结果表明，在经皮颈动脉压迫期间使用该技术测量的脑血流量可能有助于预测拟行颈动脉结扎患者的脑缺血情况。
