Fallat R J, Jewitt B, Bass M, Kamm B, Norris F H
Arch Neurol. 1979 Feb;36(2):74-80. doi: 10.1001/archneur.1979.00500380044004.
Clinical evaluation and pulmonary function tests were performed in 218 patients with motor neuron disease, mainly amyotrophic lateral sclerosis (ALS). Serial studies were obtained in 103 patients, in 31 until death from ALS. Most patients, regardless of the pattern of motor neuron involvement, had characteristic abnormalities in pulmonary function, including reduced forced vital capacity (FVC) and maximum voluntary ventilation (MVV). Reductions in the FVC and MVV to as low as 50% were commonly missed by clinical evaluators. Spirometry is therefore of value in detecting early involvement of respiratory neurons. Progressively greater reductions in the FVC and MVV in all the fatal cases indicate that serial spirometry has prognostic value in ALS.
对218例运动神经元病患者（主要为肌萎缩侧索硬化症，即ALS）进行了临床评估和肺功能测试。对103例患者进行了系列研究，其中31例直至死于ALS。大多数患者，无论运动神经元受累模式如何，肺功能均有特征性异常，包括用力肺活量（FVC）和最大自主通气量（MVV）降低。临床评估者通常会漏诊FVC和MVV降低至50%的情况。因此，肺量计在检测呼吸神经元早期受累方面具有价值。所有致命病例中FVC和MVV逐渐降低，表明系列肺量计检查对ALS具有预后价值。
