A群脑膜炎球菌多糖疫苗的对照现场试验
A controlled field trial of a serogroup A meningococcal polysaccharide vaccine.
作者信息
Wahdan M H, Rizk F, el-Akkad A M, el-Ghoroury A A, Hablas R, Girgis N I, Amer A, Boctar W, Sippel J E, Gotschlich E C, Triau R, Sanborn W R, Cvjetanović B
出版信息
Bull World Health Organ. 1973 Jun;48(6):667-73.
A controlled field trial of a serogroup A meningococcal polysaccharide vaccine was conducted at three locations in Egypt during the winter cerebrospinal meningitis (CSM) season of 1971-72. The study population consisted of schoolchildren 6-15 years of age. No cases of serogroup A meningococcal CSM occurred in the group of students vaccinated with the test vaccine whereas 8 cases occurred in the control group vaccinated with tetanus toxoid, and 151 cases occurred in an unvaccinated contrast group. The case rate was significantly different between the test and control groups as well as between the test and contrast groups but was similar between the control and contrast groups. The previously demonstrated safety of the vaccine was confirmed. A significant serological response was elicited in the majority of the vaccinated students.
1971 - 1972年冬季脑脊膜炎（CSM）流行季节，在埃及的三个地点对A群脑膜炎球菌多糖疫苗进行了一项对照现场试验。研究对象为6至15岁的学童。接种试验疫苗的学生组未出现A群脑膜炎球菌性脑脊膜炎病例，而接种破伤风类毒素的对照组出现了8例病例，未接种疫苗的对比组出现了151例病例。试验组与对照组以及试验组与对比组之间的发病率存在显著差异，但对照组与对比组之间的发病率相似。疫苗先前已证实的安全性得到了确认。大多数接种疫苗的学生出现了显著的血清学反应。
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