二氯vos处理对黄曲霉毒素产生的抑制作用及黄曲霉毒素中间体“醋酸versiconal”的初步鉴定。
Inhibition of aflatoxin production and tentative identification of an aflatoxin intermediate "versiconal acetate" from treatment with dichlorvos.
作者信息
Schroeder H W, Cole R J, Grigsby R D, Hein H
出版信息
Appl Microbiol. 1974 Feb;27(2):394-9. doi: 10.1128/am.27.2.394-399.1974.
Abstract
In general, aflatoxin production by Aspergillus flavus and A. parasiticus was greatly reduced in vitro in the presence of the insecticide dichlorvos. Reduction in yield of the toxins was accompanied by the apperance of a previously unidentified orange pigment. Spectral analyses of the pigment and of its methylated and acetylated derivatives indicated the compound to be versiconal acetate (IV). The data suggest that IV is an intermediate in the metabolic cycle that may terminate in the production of aflatoxin or of the versicolorins, or both. Dichlorvos apparently inhibits biosynthesis of the difurano ring structure common to the aflatoxins and the versicolorins.
摘要
一般来说，在杀虫剂敌敌畏存在的情况下，黄曲霉和寄生曲霉产生黄曲霉毒素的能力在体外会大幅降低。毒素产量的减少伴随着一种先前未鉴定出的橙色色素的出现。对该色素及其甲基化和乙酰化衍生物的光谱分析表明该化合物为乙酸Versiconal（IV）。数据表明IV是代谢循环中的一种中间体，该代谢循环可能以黄曲霉毒素或杂色曲霉素或两者的产生而终止。敌敌畏显然抑制了黄曲霉毒素和杂色曲霉素共有的二呋喃环结构的生物合成。
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本文引用的文献
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