杂色曲霉素A的生物合成。
Biosynthesis of versicolorin A.
作者信息
Anderson M S, Dutton M F
出版信息
Appl Environ Microbiol. 1980 Oct;40(4):706-9. doi: 10.1128/aem.40.4.706-709.1980.
Abstract
The incorporation of various potential intermediates into versicolorin A by a versicolorin A-accumulating mutant of Aspergillus parasiticus was studied. Both whole mycelium and cell-free extracts of this mutant were able to convert 14C-labeled versiconal hemiacetal acetate to versicolorin A. By the use of a labeled double substrate technique it was shown that two other compounds, versicolorin A hemiacetal and its acetate derivative, were also converted to versicolorin A. It is concluded that one or both of these compounds are intermediates in the biosynthesis of versicolorin A and therefore may possibly be involved in the biogenesis of the aflatoxins.
摘要
研究了寄生曲霉的一个积累杂色曲菌素A的突变体将各种潜在中间体掺入杂色曲菌素A的情况。该突变体的完整菌丝体和无细胞提取物都能够将14C标记的杂色曲醛半缩醛乙酸酯转化为杂色曲菌素A。通过使用标记双底物技术表明，另外两种化合物，杂色曲菌素A半缩醛及其乙酸衍生物，也被转化为杂色曲菌素A。得出的结论是，这些化合物中的一种或两种是杂色曲菌素A生物合成的中间体，因此可能参与黄曲霉毒素的生物合成。
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本文引用的文献
1
Enzymatic formation of the bisfuran structure in aflatoxin biosynthesis.黄曲霉毒素生物合成中双呋喃结构的酶促形成。
Appl Environ Microbiol. 1980 Jan;39(1):109-12. doi: 10.1128/aem.39.1.109-112.1980.
2
The structure, biochemical properties and origin of the aflatoxins B2a and G2a.黄曲霉毒素B2a和G2a的结构、生化特性及来源。
Chem Ind. 1968 Mar 30;13:418-21.
3
High aflatoxin production on a chemically defined medium.在化学成分确定的培养基上黄曲霉毒素产量高。
Appl Microbiol. 1971 Sep;22(3):393-6. doi: 10.1128/am.22.3.393-396.1971.
4
Step of dichlorvos inhibition in the pathway of aflatoxin biosynthesis.敌敌畏在黄曲霉毒素生物合成途径中的抑制步骤。
Appl Microbiol. 1974 Jul;28(1):52-7. doi: 10.1128/am.28.1.52-57.1974.
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Preparation of labeled aflatoxins with high specific activities.高比活度标记黄曲霉毒素的制备。
Appl Microbiol. 1971 Jul;22(1):79-83. doi: 10.1128/am.22.1.79-83.1971.
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Inhibition of aflatoxin production and tentative identification of an aflatoxin intermediate "versiconal acetate" from treatment with dichlorvos.二氯vos处理对黄曲霉毒素产生的抑制作用及黄曲霉毒素中间体“醋酸versiconal”的初步鉴定。
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J Agric Food Chem. 1975 Nov-Dec;23(6):1132-4. doi: 10.1021/jf60202a011.
8
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9
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10
The use of cell free extracts derived from fungal protoplasts in the study of aflatoxin biosynthesis.源自真菌原生质体的无细胞提取物在黄曲霉毒素生物合成研究中的应用。
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