敌敌畏在黄曲霉毒素生物合成途径中的抑制步骤。
Step of dichlorvos inhibition in the pathway of aflatoxin biosynthesis.
作者信息
Yao R C, Hsieh D P
出版信息
Appl Microbiol. 1974 Jul;28(1):52-7. doi: 10.1128/am.28.1.52-57.1974.
Abstract
Dichlorvos (dimethyl 2,2-dichlorovinyl phosphate) inhibits the biosynthesis of aflatoxin by Aspergillus parasiticus. Cultures treated with dichlorvos excrete an orange pigment which can be converted into aflatoxin B(1) by the untreated mycelia. The orange pigment was partially identified as an acetyl derivative of versiconol-type compound. In the presence of dichlorvos, sterigmatocystin is converted into aflatoxin B(1) without being interfered, but averufin is converted into the orange pigment instead of aflatoxin B(1). Therefore, dichlorvos appears to block an enzymatic step in the aflatoxin biosynthetic pathway, which lies beyond averufin but before sterigmatocystin, at the formation of the orange pigment.
摘要
敌敌畏（2,2-二氯乙烯基磷酸二甲酯）可抑制寄生曲霉合成黄曲霉毒素。用敌敌畏处理过的培养物会分泌一种橙色色素，这种色素可被未处理的菌丝体转化为黄曲霉毒素B(1)。该橙色色素部分被鉴定为Versiconol型化合物的乙酰衍生物。在敌敌畏存在的情况下，柄曲霉素可不受干扰地转化为黄曲霉毒素B(1)，但疣孢青霉酮却转化为橙色色素而非黄曲霉毒素B(1)。因此，敌敌畏似乎在黄曲霉毒素生物合成途径中阻断了一个酶促步骤，该步骤位于疣孢青霉酮之后、柄曲霉素之前，即在橙色色素形成时。
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