对从烧伤患者中分离出的一系列铜绿假单胞菌菌株的羧苄青霉素抗性相关R因子的分子特征分析。
Molecular characterization of the R factors implicated in the carbenicillin resistance of a sequence of Pseudomonas aeruginosa strains isolated from burns.
作者信息
Ingram L C, Richmond M H, Sykes R B
出版信息
Antimicrob Agents Chemother. 1973 Feb;3(2):279-88. doi: 10.1128/AAC.3.2.279.
Abstract
An outbreak of R-factor-mediated carbenicillin resistance in Pseudomonas aeruginosa in burned patients in March 1969 was followed by a second outbreak 6 months later. No R-factor-carrying P. aeruginosa strains were detected in the intervening period but R-factor-determined lactamase was commonly encountered, particularly in Klebsiella aerogenes strains. A comparison of the molecular properties of the R factors in pseudomonads from the first and second phases with those in the Klebsiella strains from the intervening period showed them to be very closely related. A single R-factor type therefore may have been maintained in the Burns Unit between the two Pseudomonas outbreaks as a plasmid conferring resistance to ampicillin in K. aerogenes.
摘要
1969年3月，烧伤患者中发生了由R因子介导的铜绿假单胞菌对羧苄青霉素耐药性的暴发，6个月后又发生了第二次暴发。在此期间未检测到携带R因子的铜绿假单胞菌菌株，但常见R因子决定的β-内酰胺酶，尤其是在产气克雷伯菌菌株中。对第一阶段和第二阶段假单胞菌中R因子的分子特性与中间阶段克雷伯菌菌株中的R因子分子特性进行比较，发现它们密切相关。因此，在两次铜绿假单胞菌暴发之间，烧伤病房中可能一直存在单一类型的R因子，作为一种赋予产气克雷伯菌对氨苄青霉素耐药性的质粒。
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