Michel-Briand Y, Stanisich V A, Jouvenot M
Antimicrob Agents Chemother. 1977 Apr;11(4):589-93. doi: 10.1128/AAC.11.4.589.
A plasmid, R56Be, derived from a clinical strain of Pseudomonas aeruginosa isolated in France in 1973 has been studied. This plasmid confers resistance only to carbenicillin, and although freely transferable between unrelated strains of P. aeruginosa, its transfer from P. aeruginosa to Escherichia coli K-12 was undetectable. R56Be could not be isolated as covalently closed circular deoxyribonucleic acid, but the plasmid could be transduced intact by phage F116L. This suggests that its molecular weight does not exceed that of the phage genome (ca. 40 x 10(6)). In terms of its interaction with male and female sex-specific phages, its exclusion characteristics, and the main properties of beta-lactamase determined by them, R56Be is similar to the previously characterized plasmid RP1-1.
对一种名为R56Be的质粒进行了研究，该质粒源自1973年在法国分离出的一株铜绿假单胞菌临床菌株。这种质粒仅赋予对羧苄青霉素的抗性，虽然它可在不相关的铜绿假单胞菌菌株之间自由转移，但无法检测到它从铜绿假单胞菌转移至大肠杆菌K-12。R56Be不能作为共价闭合环状脱氧核糖核酸分离出来，但该质粒可被噬菌体F116L完整转导。这表明其分子量不超过噬菌体基因组的分子量（约40×10⁶）。就其与雄性和雌性性别特异性噬菌体的相互作用、其排除特性以及由它们所决定的β-内酰胺酶的主要特性而言，R56Be与先前鉴定的质粒RP1-1相似。
