Jimerson D C, Post R M, Carman J S, van Kammen D P, Wood J H, Goodwin F K, Bunney W E
Biol Psychiatry. 1979 Feb;14(1):37-51.
In a study of electrolytes in lumbar cerebrospinal fluid (csf) from psychiatric patients, the authors found a positive correlation between calcium concentration and symptom severity in hospitalized depressed patients. CSF calcium levels tended to decrease as patients improved. In four rapidly cycling patients, CSF calcium was higher during depression than during mania. Mean CSF calcium for the depressed patients as a group was not significantly different from neurological controls or other psychiatric patients. Symptom remission from acute psychosis in schizophrenic patients was accompanied by a significant increase in CSF calcium concentration. These findings are discussed in relationship to calcium-induced alterations in neuronal and physiological excitability.
在一项针对精神病患者腰椎脑脊液（CSF）中电解质的研究中，作者发现住院抑郁症患者的钙浓度与症状严重程度呈正相关。随着患者病情好转，脑脊液钙水平趋于下降。在4名快速循环型患者中，抑郁期的脑脊液钙水平高于躁狂期。抑郁症患者组的平均脑脊液钙水平与神经科对照患者或其他精神科患者相比无显著差异。精神分裂症患者急性精神病症状缓解时，脑脊液钙浓度显著升高。这些发现结合钙诱导的神经元和生理兴奋性改变进行了讨论。
