Levine J, Stein D, Rapoport A, Kurtzman L
Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel.
Neuropsychobiology. 1999;39(2):63-70. doi: 10.1159/000026562.
Calcium (Ca) and magnesium (Mg) are involved in many processes related to depression. Evaluations of serum and plasma Ca and Mg levels in depressive disorders do not show consistent results. The few studies that examined their cerebrospinal fluid (CSF) levels tended to find no differences between depressed patients and controls. Because both hypercalcemia and hypomagnesemia are associated with depression, and as Mg may function as a Ca antagonist, it is suggested that the relationship between these cations could be different in depressed patients and controls. We examined CSF and serum Ca and Mg in acutely depressed patients diagnosed as having major depressive disorder or being in a depressive episode of bipolar disorder. Controls were subjects undergoing lumbar puncture as part of an evaluation for headache or suspected meningitis and found to demonstrate no physical or mental disorder. Serum and CSF Ca/Mg ratios were found to be elevated in the depressed patients compared with the controls. A retrospective analysis of previous trials assessing serum/plasma or CSF Ca and Mg does not seem to refute the findings of this study. We further discuss our findings in their relation to the acuteness of the depressive disorders.
钙（Ca）和镁（Mg）参与许多与抑郁症相关的过程。对抑郁症患者血清和血浆中钙和镁水平的评估结果并不一致。少数检测脑脊液（CSF）中钙和镁水平的研究往往未发现抑郁症患者与对照组之间存在差异。由于高钙血症和低镁血症均与抑郁症有关，且镁可能起到钙拮抗剂的作用，因此有人提出，这些阳离子之间的关系在抑郁症患者和对照组中可能有所不同。我们检测了被诊断为重度抑郁症或双相情感障碍抑郁发作的急性抑郁症患者的脑脊液和血清中的钙和镁。对照组为因头痛评估或疑似脑膜炎而接受腰椎穿刺且未发现身体或精神疾病的受试者。结果发现，与对照组相比，抑郁症患者血清和脑脊液中的钙/镁比值升高。对以往评估血清/血浆或脑脊液中钙和镁的试验进行回顾性分析，似乎并未反驳本研究的结果。我们将进一步讨论我们的研究结果与抑郁症急性程度的关系。
