Tatár M, Korpás J
Physiol Bohemoslov. 1979;28(5):411-7.
The authors induced experimental hydrothorax in cats by injecting dextran into the pleural cavity under brief N2O anaesthesia. They examined the parameters of cough -- elicited by mechanical stimulation of the airway mucosa -- and blood gas and pH values under normal conditions and after the injection of 50, 100, 200 and 250 ml dextran. The tests were always performed 30 min after terminating anaesthesia, i.e. in conscious animals. The free fluid in the thorax was found, in conscious cats, to reduce the inspiratory values of cough, but to have no effect on cough expiration. This is in agreement with previous findings showing that the intensity of a cough expiration does not always depend on the intensity of the preceding cough inspiration. According to this finding, the decrease in the expiratory values of cough observed during experimental pleurisy cannot be due to the actual exudate. In cats, experimental hydrothorax in doses of 200 and 250 ml leads to respiratory insufficiency. The authors further found that, for the study of interoception in the airways of conscious cats, which requires experimental induction of pathological conditions under brief anaesthesia, nitrous oxide is a convenient anesthetic.
作者在短暂的一氧化二氮麻醉下，通过向猫的胸腔内注射右旋糖酐诱导实验性胸腔积液。他们检测了在正常情况下以及注射50、100、200和250毫升右旋糖酐后，由气道黏膜机械刺激引发的咳嗽参数、血气和pH值。这些测试总是在麻醉结束后30分钟进行，即在清醒动物身上进行。在清醒的猫身上发现，胸腔内的游离液体可降低咳嗽的吸气值，但对咳嗽呼气没有影响。这与先前的研究结果一致，即咳嗽呼气的强度并不总是取决于先前咳嗽吸气的强度。根据这一发现，实验性胸膜炎期间观察到的咳嗽呼气值降低并非由于实际的渗出液。在猫身上，200和250毫升剂量的实验性胸腔积液会导致呼吸功能不全。作者还进一步发现，对于在清醒猫的气道中进行内感受研究，这需要在短暂麻醉下实验性诱导病理状况，一氧化二氮是一种方便的麻醉剂。
