Fedorov V I, Perov Iu L
Biull Eksp Biol Med. 1979 Feb;87(2):128-32.
Adrenal incompetence developed in rats 6 weeks after adrenalectomy without any salt and hormonal compensation. In individual fragments of the isolated glomeruli containing juxtaglomerular cells (JGC) renin activity increased 1.2 times on the average, and there was revealed renin-like activity (RLA) in the fragments containing mesangial cells (MC). Signs of intensified renin secretion (expressed in reduction of granule count, marked development of granular endoplasmic reticulum, Golgi complex and microtubules) were noted in the JGC. In MC such organoids were well developed, but no granules were revealed. The following occurred in 8 to 12 weeks with the restoration of the 11-OCS and sodium level in the plasma: renin JGC activity became normal, RLA activity in MC disappeared, and the initial ultrastructure of both of these cells was restored. The reserve role of MC as the source of renin-like substances was confirmed.
在大鼠肾上腺切除术后 6 周，在未给予任何盐分和激素补偿的情况下出现了肾上腺功能不全。在含有球旁细胞（JGC）的分离肾小球的各个片段中，肾素活性平均增加了 1.2 倍，并且在含有系膜细胞（MC）的片段中发现了肾素样活性（RLA）。在 JGC 中观察到肾素分泌增强的迹象（表现为颗粒数量减少、粗面内质网、高尔基体复合体和微管显著发育）。在 MC 中，此类细胞器发育良好，但未发现颗粒。在血浆中 11 - OCS 和钠水平恢复后的 8 至 12 周出现了以下情况：JGC 的肾素活性恢复正常，MC 中的 RLA 活性消失，并且这两种细胞的初始超微结构得以恢复。证实了 MC 作为肾素样物质来源的储备作用。
