Hamada S, Torizuka K, Uete T
J Clin Pathol. 1974 May;27(5):377-81. doi: 10.1136/jcp.27.5.377.
A simple method is described for the simultaneous determinations of thyroxine and the effective thyroxine ratio (ETR) using a single kit of Thyopac-4. Thyopac ETR values obtained were 1.00 +/- 0.03 for normal subjects; 1.22 +/- 0.11 for hyperthyroid; 0.87 +/- 0.04 for hypothyroid; and 1.02 +/- 0.05 for pregnant women. Cases with TBG deficiency and the nephrotic syndrome indicated normal values. The value (x) was correlated significantly (gamma = + 0.961) with the free Thyopac index (y), representing a regression equation of y = 71.7x(2) - 88.4x + 24.2. Thyopac ETR was shown to be useful in differentiating normal thyroid states from abnormal, irrespective of changes in T(4)-binding globulin (TBG). Further, the T(4) value obtained simultaneously made it possible to detect changes in the TBG level by noting an inconsistent value for the effective thyroxine ratio.
本文描述了一种使用单一的Thyopac - 4试剂盒同时测定甲状腺素和有效甲状腺素比率（ETR）的简单方法。正常受试者的Thyopac ETR值为1.00±0.03；甲状腺功能亢进者为1.22±0.11；甲状腺功能减退者为0.87±0.04；孕妇为1.02±0.05。甲状腺素结合球蛋白（TBG）缺乏症患者和肾病综合征患者的数值显示正常。该值（x）与游离Thyopac指数（y）显著相关（γ = + 0.961），其回归方程为y = 71.7x² - 88.4x + 24.2。结果表明，无论甲状腺素结合球蛋白（TBG）如何变化，Thyopac ETR对于区分正常和异常甲状腺状态均有用。此外，同时获得的甲状腺素（T4）值使得通过有效甲状腺素比率值的不一致来检测TBG水平的变化成为可能。
