血清中利福平的测定
Assay of rifampicin in serum.
作者信息
Dickinson J M, Aber V R, Allen B W, Ellard G A, Mitchison D A
出版信息
J Clin Pathol. 1974 Jun;27(6):457-62. doi: 10.1136/jcp.27.6.457.
Abstract
Two methods for the assay of rifampicin in serum are described. The first is a conventional plate diffusion method, measuring concentrations down to 0.02 mug/ml, and the second a chemical extraction followed by measurement of the inhibition of uptake of (14)C-uridine by Staphylococcus aureus, which estimates in the range of 0.02 to 0.001 mug/ml. The methods were used to measure serum concentrations in man following doses of about 1050 mg and 75 mg rifampicin.
摘要
本文描述了两种测定血清中利福平的方法。第一种是传统的平板扩散法，可检测低至0.02微克/毫升的浓度；第二种是化学提取法，随后测定金黄色葡萄球菌对（14）C - 尿苷摄取的抑制作用，其估计范围为0.02至0.001微克/毫升。这些方法用于测定人体在服用约1050毫克和75毫克利福平后的血清浓度。
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本文引用的文献
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A VERTICAL DIFFUSION METHOD FOR THE MICROBIOLOGICAL ASSAY OF ISONIAZID.异烟肼微生物测定的垂直扩散法
J Clin Pathol. 1964 Nov;17(6):622-6. doi: 10.1136/jcp.17.6.622.
2
Rifampicin: a new rifamycin. 3. Absorption, distribution, and elimination in man.利福平：一种新型利福霉素。3. 人体中的吸收、分布及消除
Arzneimittelforschung. 1967 May;17(5):534-7.
3
Detection of rifampicin in urine by a simple microbiological assay.通过一种简单的微生物学检测法检测尿液中的利福平。
Tubercle. 1970 Sep;51(3):300-4. doi: 10.1016/0041-3879(70)90023-1.
4
Potentially serious side effects of high-dose twice-weekly rifampicin.高剂量每周两次利福平潜在的严重副作用。
Br Med J. 1971 Aug 7;3(5770):343-7. doi: 10.1136/bmj.3.5770.343.
5
[Comparative study of the development of rifomycin blood levels in humans by 2 different microbiologic methods].[两种不同微生物学方法测定人利福霉素血药浓度的比较研究]
Rev Tuberc Pneumol (Paris). 1970;34(1):93-106.
6
Suitability of rifampicin for intermittent administration in the treatment of tuberculosis.利福平间歇给药治疗结核病的适用性。
Tubercle. 1970 Mar;51(1):82-94. doi: 10.1016/0041-3879(70)90131-5.
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Desacetyl-rifamycins: preparation and antibacterial properties.去乙酰利福霉素：制备及其抗菌特性
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