Carter P B, Collins F M
Infect Immun. 1974 Oct;10(4):816-22. doi: 10.1128/iai.10.4.816-822.1974.
The in vivo growth of Salmonella paratyphi A, S. paratyphi B, S. paratyphi C, and S. typhi, as well as of an S. typhi-typhimurium hybrid, was studied in three different strains of mice. S. paratyphi A and B and S. typhi demonstrated very little growth potential in any of the intravenously infected mice, even after as many as 20 serial mouse passages. It was noted, however, that small numbers of viable S. paratyphi B and S. typhi persisted in the spleens of infected mice for up to 28 days. Salmonella paratyphi C and the S. typhi-typhimurium hybrid gave rise to progressive systemic infections beginning from very small intravenous inocula. The median lethal doses for the C57B1 strain of mouse were about five organisms. The relevance of these findings with regard to the development of an animal model for studying human typhoid fever vaccines is discussed.
在三种不同品系的小鼠中研究了甲型副伤寒沙门氏菌、乙型副伤寒沙门氏菌、丙型副伤寒沙门氏菌、伤寒沙门氏菌以及伤寒-鼠伤寒沙门氏菌杂交菌株的体内生长情况。甲型副伤寒沙门氏菌、乙型副伤寒沙门氏菌和伤寒沙门氏菌在任何静脉感染的小鼠中生长潜力都非常小，即使经过多达20次连续的小鼠传代也是如此。然而，值得注意的是，少量存活的乙型副伤寒沙门氏菌和伤寒沙门氏菌在感染小鼠的脾脏中可存活长达28天。丙型副伤寒沙门氏菌和伤寒-鼠伤寒沙门氏菌杂交菌株从非常小的静脉接种量开始就引发进行性全身感染。C57B1品系小鼠的半数致死剂量约为五个菌体。讨论了这些发现与开发用于研究人类伤寒热疫苗的动物模型的相关性。
