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The analog inhibitor, alpha-methyl dopa, as a screening agent for mutants elevating levels of dopa decarboxylase activity in Drosophila melanogaster.

作者信息

Sherald A F, Wright T R

出版信息

Mol Gen Genet. 1974;133(1):25-36. doi: 10.1007/BF00268674.

DOI:10.1007/BF00268674
PMID:4214992
Abstract
摘要

相似文献

1
The analog inhibitor, alpha-methyl dopa, as a screening agent for mutants elevating levels of dopa decarboxylase activity in Drosophila melanogaster.模拟抑制剂α-甲基多巴作为筛选果蝇中提高多巴脱羧酶活性水平突变体的试剂。
Mol Gen Genet. 1974;133(1):25-36. doi: 10.1007/BF00268674.
2
The selection for mutants in Drosophila melanogaster hypersensitive to alpha-methyl dopa, a dopa decarboxylase inhibitor.对α-甲基多巴（一种多巴脱羧酶抑制剂）敏感的黑腹果蝇突变体的筛选。
Mol Gen Genet. 1974 May 21;130(2):127-41. doi: 10.1007/BF00269084.
3
A kinetic analysis of Drosophila melanogaster dopa decarboxylase.黑腹果蝇多巴脱羧酶的动力学分析
Biochim Biophys Acta. 1986 Mar 7;870(1):31-40. doi: 10.1016/0167-4838(86)90005-1.
4
Evidence for regulatory variants of the dopa decarboxylase and alpha-methyldopa hypersensitive loci in Drosophila.果蝇中多巴脱羧酶和α-甲基多巴超敏位点调控变体的证据。
Genetics. 1986 Feb;112(2):249-65. doi: 10.1093/genetics/112.2.249.
5
The genetics of dopa decarboxylase in Drosophila melanogaster. I. Isolation and characterization of deficiencies that delete the dopa-decarboxylase-dosage-sensitive region and the alpha-methyl-dopa-hypersensitive locus.黑腹果蝇中多巴脱羧酶的遗传学。I. 缺失多巴脱羧酶剂量敏感区域和α-甲基多巴超敏位点的缺陷型的分离与特性分析。
Genetics. 1976 Oct;84(2):267-85. doi: 10.1093/genetics/84.2.267.
6
The genetics of dopa decarboxylase in Drosophila melanogaster. II. Isolation and characterization of dopa-decarboxylase-deficient mutants and their relationship to the alpha-methyl-dopa-hypersensitive mutants.黑腹果蝇中多巴脱羧酶的遗传学。II. 多巴脱羧酶缺陷型突变体的分离与鉴定及其与α-甲基多巴超敏突变体的关系。
Genetics. 1976 Oct;84(2):287-310. doi: 10.1093/genetics/84.2.287.
7
The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism.果蝇中的α-甲基多巴超敏基因1(2)amd及两个相邻基因：物理定位和amd对儿茶酚胺代谢的直接影响
Mol Gen Genet. 1987 Sep;209(2):306-12. doi: 10.1007/BF00329658.
8
DOPA decarboxylase activity in the nervous system and the ctenidium of the freshwater clam, Musculium (Sphaerium) transversum.
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(1):55-7. doi: 10.1016/0742-8413(84)90129-4.
9
Use of radiolabeled monofluoromethyl-Dopa to define the subunit structure of human L-Dopa decarboxylase.使用放射性标记的单氟甲基多巴来确定人L-多巴脱羧酶的亚基结构。
Biochemistry. 1983 Dec 20;22(26):6058-63. doi: 10.1021/bi00295a003.
10
Characterization of third chromosome dominant alpha-methyl dopa resistant mutants (Tcr) and their interactions with l(2)amd alpha-methyl dopa hypersensitive alleles in Drosophila melanogaster.黑腹果蝇中第三条染色体显性α-甲基多巴抗性突变体（Tcr）的特征及其与l(2)amdα-甲基多巴超敏等位基因的相互作用。
Genet Res. 1989 Oct;54(2):93-9. doi: 10.1017/s0016672300028469.

引用本文的文献

1
Dopamine dynamics and signaling in Drosophila: an overview of genes, drugs and behavioral paradigms.果蝇中的多巴胺动态与信号传导：基因、药物及行为范式概述
Exp Anim. 2014;63(2):107-19. doi: 10.1538/expanim.63.107.
2
From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.从左旋多巴到二羟苯乙酸醛：有毒的生化途径在昆虫中起着至关重要的生理功能。
PLoS One. 2011 Jan 24;6(1):e16124. doi: 10.1371/journal.pone.0016124.
3
The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region.

本文引用的文献

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Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
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[On tyrosine metabolism in insects. VI. Identification of N-acetyl-3,4-dihydroxy-beta-phenylethylamine (N-acetyl-dopamine) as a tyrosine metabolite].[昆虫酪氨酸代谢。VI. N-乙酰-3,4-二羟基-β-苯乙胺（N-乙酰多巴胺）作为酪氨酸代谢产物的鉴定]
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ECDYSONE DURING INSECT DEVELOPMENT. 3. ACTIVITIES OF SOME ENZYMES OF TYROSINE METABOLISM IN COMPARISON WITH ECDYSONE TITER DURING THE DEVELOPMENT OF THE BLOWFLY, CALLIPHORA ERYTHROCEPHIA MEIG.
黑腹果蝇中多巴脱羧酶的遗传学。IV. 37B10 - 37D1区域的遗传学与细胞学
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Genetic and biochemical properties of revertants at the rudimentary locus in Drosophila melanogaster.黑腹果蝇 rudimentary 基因座回复突变体的遗传与生化特性
Mol Gen Genet. 1981;183(2):270-6. doi: 10.1007/BF00270628.
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The genetics of dopa decarboxylase in Drosophila melanogaster. II. Isolation and characterization of dopa-decarboxylase-deficient mutants and their relationship to the alpha-methyl-dopa-hypersensitive mutants.黑腹果蝇中多巴脱羧酶的遗传学。II. 多巴脱羧酶缺陷型突变体的分离与鉴定及其与α-甲基多巴超敏突变体的关系。
Genetics. 1976 Oct;84(2):287-310. doi: 10.1093/genetics/84.2.287.
6
The genetics of dopa decarboxylase in Drosophila melanogaster. I. Isolation and characterization of deficiencies that delete the dopa-decarboxylase-dosage-sensitive region and the alpha-methyl-dopa-hypersensitive locus.黑腹果蝇中多巴脱羧酶的遗传学。I. 缺失多巴脱羧酶剂量敏感区域和α-甲基多巴超敏位点的缺陷型的分离与特性分析。
Genetics. 1976 Oct;84(2):267-85. doi: 10.1093/genetics/84.2.267.
昆虫发育过程中的蜕皮激素。3. 与红头丽蝇（Calliphora erythrocephala Meig.）发育过程中蜕皮激素滴度相比，酪氨酸代谢的一些酶的活性
Gen Comp Endocrinol. 1965 Feb;5:35-9. doi: 10.1016/0016-6480(65)90066-3.
4
ON THE MECHANISM OF HORMONE ACTION. II. ECDYSONE AND PROTEIN BIOSYNTHESIS.论激素作用机制。II. 蜕皮激素与蛋白质生物合成
Arch Biochem Biophys. 1964 Jun;105:483-7. doi: 10.1016/0003-9861(64)90039-6.
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[ON TYROSINE METABOLISM IN INSECTS. XII. PURIFICATION, PROPERTIES AND SUBSTRATE SPECIFICITY OF DOPA-DECARBOXYLASE].
Hoppe Seylers Z Physiol Chem. 1963;332:70-8. doi: 10.1515/bchm2.1963.332.1.70.
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[On tyrosine metabolism of insects. IX. Control of tyrosine metabolism by ecdysone].[昆虫酪氨酸代谢。IX. 蜕皮激素对酪氨酸代谢的调控]
Biochim Biophys Acta. 1962 Oct 8;63:489-95. doi: 10.1016/0006-3002(62)90112-9.
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[on tyrosine metabolism by insects. VII. The catabolic decomposition of tyrosine and the biogenesis of the sclerotizing substance, N-acetyldopamine].[关于昆虫的酪氨酸代谢。VII. 酪氨酸的分解代谢及硬化物质N-乙酰多巴胺的生物合成]
Biochim Biophys Acta. 1962 Jul 30;62:103-13. doi: 10.1016/0006-3002(62)90495-x.
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[A method for determining aromatic amino acid decarboxylase].
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[On tyrosine metabolism in insects. XVII. The tyrosine metabolism of Tenebrie molitor and Drosophila melanogaster].
Hoppe Seylers Z Physiol Chem. 1966;344(4):267-75.
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Biosynthesis of catecholamines in insects.昆虫中儿茶酚胺的生物合成。
Pharmacol Rev. 1966 Mar;18(1):89-94.