模拟抑制剂α-甲基多巴作为筛选果蝇中提高多巴脱羧酶活性水平突变体的试剂。 - Suppr

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The analog inhibitor, alpha-methyl dopa, as a screening agent for mutants elevating levels of dopa decarboxylase activity in Drosophila melanogaster.

作者信息

Sherald A F, Wright T R

出版信息

Mol Gen Genet. 1974;133(1):25-36. doi: 10.1007/BF00268674.

DOI:10.1007/BF00268674

PMID:4214992

Abstract

摘要

相似文献

The analog inhibitor, alpha-methyl dopa, as a screening agent for mutants elevating levels of dopa decarboxylase activity in Drosophila melanogaster.模拟抑制剂α-甲基多巴作为筛选果蝇中提高多巴脱羧酶活性水平突变体的试剂。

Mol Gen Genet. 1974;133(1):25-36. doi: 10.1007/BF00268674.

The selection for mutants in Drosophila melanogaster hypersensitive to alpha-methyl dopa, a dopa decarboxylase inhibitor.对α-甲基多巴（一种多巴脱羧酶抑制剂）敏感的黑腹果蝇突变体的筛选。

Mol Gen Genet. 1974 May 21;130(2):127-41. doi: 10.1007/BF00269084.

A kinetic analysis of Drosophila melanogaster dopa decarboxylase.黑腹果蝇多巴脱羧酶的动力学分析

Biochim Biophys Acta. 1986 Mar 7;870(1):31-40. doi: 10.1016/0167-4838(86)90005-1.

Evidence for regulatory variants of the dopa decarboxylase and alpha-methyldopa hypersensitive loci in Drosophila.果蝇中多巴脱羧酶和α-甲基多巴超敏位点调控变体的证据。

Genetics. 1986 Feb;112(2):249-65. doi: 10.1093/genetics/112.2.249.

The genetics of dopa decarboxylase in Drosophila melanogaster. I. Isolation and characterization of deficiencies that delete the dopa-decarboxylase-dosage-sensitive region and the alpha-methyl-dopa-hypersensitive locus.黑腹果蝇中多巴脱羧酶的遗传学。I. 缺失多巴脱羧酶剂量敏感区域和α-甲基多巴超敏位点的缺陷型的分离与特性分析。

Genetics. 1976 Oct;84(2):267-85. doi: 10.1093/genetics/84.2.267.

The genetics of dopa decarboxylase in Drosophila melanogaster. II. Isolation and characterization of dopa-decarboxylase-deficient mutants and their relationship to the alpha-methyl-dopa-hypersensitive mutants.黑腹果蝇中多巴脱羧酶的遗传学。II. 多巴脱羧酶缺陷型突变体的分离与鉴定及其与α-甲基多巴超敏突变体的关系。

Genetics. 1976 Oct;84(2):287-310. doi: 10.1093/genetics/84.2.287.

The alpha methyl dopa hypersensitive gene, 1(2)amd, and two adjacent genes in Drosophila melanogaster: physical location and direct effects of amd on catecholamine metabolism.果蝇中的α-甲基多巴超敏基因1(2)amd及两个相邻基因：物理定位和amd对儿茶酚胺代谢的直接影响

Mol Gen Genet. 1987 Sep;209(2):306-12. doi: 10.1007/BF00329658.

DOPA decarboxylase activity in the nervous system and the ctenidium of the freshwater clam, Musculium (Sphaerium) transversum.

Comp Biochem Physiol C Comp Pharmacol Toxicol. 1984;77(1):55-7. doi: 10.1016/0742-8413(84)90129-4.

Use of radiolabeled monofluoromethyl-Dopa to define the subunit structure of human L-Dopa decarboxylase.使用放射性标记的单氟甲基多巴来确定人L-多巴脱羧酶的亚基结构。

Biochemistry. 1983 Dec 20;22(26):6058-63. doi: 10.1021/bi00295a003.

Characterization of third chromosome dominant alpha-methyl dopa resistant mutants (Tcr) and their interactions with l(2)amd alpha-methyl dopa hypersensitive alleles in Drosophila melanogaster.黑腹果蝇中第三条染色体显性α-甲基多巴抗性突变体（Tcr）的特征及其与l(2)amdα-甲基多巴超敏等位基因的相互作用。

Genet Res. 1989 Oct;54(2):93-9. doi: 10.1017/s0016672300028469.

引用本文的文献

Dopamine dynamics and signaling in Drosophila: an overview of genes, drugs and behavioral paradigms.果蝇中的多巴胺动态与信号传导：基因、药物及行为范式概述

Exp Anim. 2014;63(2):107-19. doi: 10.1538/expanim.63.107.

From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.从左旋多巴到二羟苯乙酸醛：有毒的生化途径在昆虫中起着至关重要的生理功能。

PLoS One. 2011 Jan 24;6(1):e16124. doi: 10.1371/journal.pone.0016124.

The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region.黑腹果蝇中多巴脱羧酶的遗传学。IV. 37B10 - 37D1区域的遗传学与细胞学

Chromosoma. 1981;83(1):45-58. doi: 10.1007/BF00286015.

Genetic and biochemical properties of revertants at the rudimentary locus in Drosophila melanogaster.黑腹果蝇 rudimentary 基因座回复突变体的遗传与生化特性

Mol Gen Genet. 1981;183(2):270-6. doi: 10.1007/BF00270628.

Genetics. 1976 Oct;84(2):287-310. doi: 10.1093/genetics/84.2.287.

Genetics. 1976 Oct;84(2):267-85. doi: 10.1093/genetics/84.2.267.

本文引用的文献

Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。

J Biol Chem. 1951 Nov;193(1):265-75.

[On tyrosine metabolism in insects. VI. Identification of N-acetyl-3,4-dihydroxy-beta-phenylethylamine (N-acetyl-dopamine) as a tyrosine metabolite].[昆虫酪氨酸代谢。VI. N-乙酰-3,4-二羟基-β-苯乙胺（N-乙酰多巴胺）作为酪氨酸代谢产物的鉴定]

Hoppe Seylers Z Physiol Chem. 1962 May 4;327:86-94. doi: 10.1515/bchm2.1962.327.1.86.

ECDYSONE DURING INSECT DEVELOPMENT. 3. ACTIVITIES OF SOME ENZYMES OF TYROSINE METABOLISM IN COMPARISON WITH ECDYSONE TITER DURING THE DEVELOPMENT OF THE BLOWFLY, CALLIPHORA ERYTHROCEPHIA MEIG.昆虫发育过程中的蜕皮激素。3. 与红头丽蝇（Calliphora erythrocephala Meig.）发育过程中蜕皮激素滴度相比，酪氨酸代谢的一些酶的活性

Gen Comp Endocrinol. 1965 Feb;5:35-9. doi: 10.1016/0016-6480(65)90066-3.

ON THE MECHANISM OF HORMONE ACTION. II. ECDYSONE AND PROTEIN BIOSYNTHESIS.论激素作用机制。II. 蜕皮激素与蛋白质生物合成

Arch Biochem Biophys. 1964 Jun;105:483-7. doi: 10.1016/0003-9861(64)90039-6.

[ON TYROSINE METABOLISM IN INSECTS. XII. PURIFICATION, PROPERTIES AND SUBSTRATE SPECIFICITY OF DOPA-DECARBOXYLASE].

Hoppe Seylers Z Physiol Chem. 1963;332:70-8. doi: 10.1515/bchm2.1963.332.1.70.

[On tyrosine metabolism of insects. IX. Control of tyrosine metabolism by ecdysone].[昆虫酪氨酸代谢。IX. 蜕皮激素对酪氨酸代谢的调控]

Biochim Biophys Acta. 1962 Oct 8;63:489-95. doi: 10.1016/0006-3002(62)90112-9.

[on tyrosine metabolism by insects. VII. The catabolic decomposition of tyrosine and the biogenesis of the sclerotizing substance, N-acetyldopamine].[关于昆虫的酪氨酸代谢。VII. 酪氨酸的分解代谢及硬化物质N-乙酰多巴胺的生物合成]

Biochim Biophys Acta. 1962 Jul 30;62:103-13. doi: 10.1016/0006-3002(62)90495-x.

[A method for determining aromatic amino acid decarboxylase].

Biochim Biophys Acta. 1967 May 16;139(1):193-5. doi: 10.1016/0005-2744(67)90132-5.

[On tyrosine metabolism in insects. XVII. The tyrosine metabolism of Tenebrie molitor and Drosophila melanogaster].

Hoppe Seylers Z Physiol Chem. 1966;344(4):267-75.

Biosynthesis of catecholamines in insects.昆虫中儿茶酚胺的生物合成。

Pharmacol Rev. 1966 Mar;18(1):89-94.

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