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1
Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity.具有抗半抗原活性的小鼠骨髓瘤蛋白重链（α链）可变区的氨基酸序列。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1123-7. doi: 10.1073/pnas.71.4.1123.
2
Variable region sequence of the heavy chain from a phosphorylcholine binding myeloma protein.一种磷酸胆碱结合性骨髓瘤蛋白重链的可变区序列
Biochemistry. 1974 Sep 10;13(19):4033-8. doi: 10.1021/bi00716a034.
3
Variable region sequences of five human immunoglobulin heavy chains of the VH3 subgroup: definitive identification of four heavy chain hypervariable regions.VH3亚组的五条人免疫球蛋白重链的可变区序列：四个重链高变区的明确鉴定
Proc Natl Acad Sci U S A. 1974 Mar;71(3):845-8. doi: 10.1073/pnas.71.3.845.
4
Amino acid sequence of the light chain of a mouse myeloma protein (MOPC-315).一种小鼠骨髓瘤蛋白（MOPC - 315）轻链的氨基酸序列。
Biochemistry. 1973 Dec 18;12(26):5400-16.
5
Mouse immunoglobulin kappa chain MPC 11: extra amino-terminal residues.小鼠免疫球蛋白κ链MPC 11：额外的氨基末端残基
Science. 1973 Sep 7;181(4103):941-3. doi: 10.1126/science.181.4103.941.
6
Glycopeptides of heavy chains from human IgA myeloma proteins.人IgA骨髓瘤蛋白重链的糖肽
J Immunol. 1974 May;112(5):1623-7.
7
Association of S-IgA subunits.分泌型免疫球蛋白A亚基的关联
Adv Exp Med Biol. 1974;45(0):99-109. doi: 10.1007/978-1-4613-4550-3_11.
8
Affinity-labeled peptides obtained from the combining region of myeloma protein 460. I. Heavy-chain-labeling patterns using dinitrophenyl azide photoaffinity label.从骨髓瘤蛋白460的结合区域获得的亲和标记肽。I. 使用二硝基苯基叠氮化物光亲和标记的重链标记模式。
Biochemistry. 1974 Aug 13;13(17):3567-71. doi: 10.1021/bi00714a025.
9
Mouse lambda-chain sequences.小鼠λ链序列。
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2112-6. doi: 10.1073/pnas.70.7.2112.
10
Localization of idiotypic antigenic determinants in the Fv region of murine myeloma protein MOPC-315.小鼠骨髓瘤蛋白MOPC - 315的Fv区域中独特型抗原决定簇的定位
Proc Natl Acad Sci U S A. 1973 May;70(5):1585-7. doi: 10.1073/pnas.70.5.1585.

引用本文的文献

1
Helper T cell recognition of the variable domains of a mouse myeloma protein (315). Effect of the major histocompatibility complex and domain conformation.辅助性T细胞对小鼠骨髓瘤蛋白可变区的识别（315）。主要组织相容性复合体和结构域构象的影响。
J Exp Med. 1982 Jun 1;155(6):1587-96. doi: 10.1084/jem.155.6.1587.
2
Structural studies on induced antibodies with defined idiotypic specificities. IX. Framework differences in the heavy- and light-chain-variable regions of monoclonal anti-p-azophenylarsonate antibodies from A/J mice differing with respect to a cross-reactive idiotype.具有明确独特型特异性的诱导抗体的结构研究。IX. 来自A/J小鼠的单克隆抗对氨基苯砷酸盐抗体重链和轻链可变区在交叉反应独特型方面的框架差异。
J Exp Med. 1980 Apr 1;151(4):863-75. doi: 10.1084/jem.151.4.863.
3
A small hypervariable segment in the variable domain of an immunoglobulin light chain stimulates formation of anti-idiotypic suppressor T cells.免疫球蛋白轻链可变域中的一个小的高变区刺激抗独特型抑制性T细胞的形成。
Proc Natl Acad Sci U S A. 1982 Sep;79(17):5396-400. doi: 10.1073/pnas.79.17.5396.
4
Structural bases for public idiotypic specificities of monoclonal antibodies directed against poly(Glu60Ala30Tyr10) and poly(Glu60Ala40) random copolymers.针对聚（Glu60Ala30Tyr10）和聚（Glu60Ala40）无规共聚物的单克隆抗体的公共独特型特异性的结构基础
Proc Natl Acad Sci U S A. 1983 May;80(10):3040-4. doi: 10.1073/pnas.80.10.3040.
5
The three-dimensional structure of a phosphorylcholine-binding mouse immunoglobulin Fab and the nature of the antigen binding site.一种结合磷酸胆碱的小鼠免疫球蛋白Fab的三维结构及抗原结合位点的性质。
Proc Natl Acad Sci U S A. 1974 Nov;71(11):4298-302. doi: 10.1073/pnas.71.11.4298.
6
The three-dimensional structure of the fab' fragment of a human myeloma immunoglobulin at 2.0-angstrom resolution.人骨髓瘤免疫球蛋白Fab'片段在2.0埃分辨率下的三维结构。
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3440-4. doi: 10.1073/pnas.71.9.3440.
7
Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes.小鼠免疫球蛋白重链由多个种系可变区基因编码。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4096-100. doi: 10.1073/pnas.71.10.4096.
8
The strange cross-reaction of menadione (vitamin K3) and 2,4-dinitrophenyl ligands with a myeloma protein and some conventional antibodies.甲萘醌（维生素K3）和2,4-二硝基苯基配体与一种骨髓瘤蛋白及一些传统抗体的奇特交叉反应。
J Exp Med. 1974 Sep 1;140(3):687-702. doi: 10.1084/jem.140.3.687.
9
Two types of immunoglobulin-negative Abelson murine leukemia virus-transformed cells: implications for B-lymphocyte differentiation.两种免疫球蛋白阴性的阿贝尔森鼠白血病病毒转化细胞：对B淋巴细胞分化的意义。
Proc Natl Acad Sci U S A. 1986 Jan;83(1):145-9. doi: 10.1073/pnas.83.1.145.
10
Fine specificity analysis of idiotype-specific suppressor factors that block a delayed-type hypersensitivity response to M315: evidence supporting a role for somatic mutations in the variable region of the lambda 2 chain of M315.对阻断针对M315的迟发型超敏反应的独特型特异性抑制因子的精细特异性分析：支持M315的λ2链可变区体细胞突变起作用的证据。
Immunology. 1986 Nov;59(3):365-72.

本文引用的文献

1
Reversible blocking of peptide amino groups by maleic anhydride.马来酸酐对肽氨基的可逆封闭
Biochem J. 1967 Jun;103(3):78P-79P.
2
An improved method of testing for evolutionary homology.一种改进的进化同源性测试方法。
J Mol Biol. 1966 Mar;16(1):9-16. doi: 10.1016/s0022-2836(66)80258-9.
3
The covalent structure of a human gamma G-immunoglobulin. XI. Functional implications.人γ-G免疫球蛋白的共价结构。XI. 功能意义。
Biochemistry. 1970 Aug 4;9(16):3197-205. doi: 10.1021/bi00818a012.
4
Three variable-gene pools common to IgM, IgG and IgA immunoglobulins.IgM、IgG和IgA免疫球蛋白共有的三个可变基因库。
Nature. 1970 Sep 26;227(5265):1318-20. doi: 10.1038/2271318a0.
5
Amino acid sequence analysis with methyl isothiocyanate. Resolution of the methylthiohydantoins by gas-liquid partition chromatography.用异硫氰酸甲酯进行氨基酸序列分析。通过气液分配色谱法分离甲硫基乙内酰脲。
Biochemistry. 1970 Feb 17;9(4):832-9. doi: 10.1021/bi00806a016.
6
Macroglobulin structure: variable sequence of light and heavy chains.巨球蛋白结构：轻链和重链的可变序列。
Science. 1970 Jul 3;169(3940):56-9. doi: 10.1126/science.169.3940.56.
7
Experimental approaches to homogenous antibody populations. Myeloma proteins with antihapten antibody activity.针对同源抗体群体的实验方法。具有抗半抗原抗体活性的骨髓瘤蛋白。
Fed Proc. 1970 Jan-Feb;29(1):78-84.
8
The amino acid sequence of bovine carboxypeptidase A. II. Tryptic and chymotryptic peptides of the cyanogen bromide fragment F-III.牛羧肽酶A的氨基酸序列。II. 溴化氰片段F-III的胰蛋白酶和胰凝乳蛋白酶肽段
Biochemistry. 1969 Sep;8(9):3859-71. doi: 10.1021/bi00837a052.
9
Attempts to locate complementarity-determining residues in the variable positions of light and heavy chains.尝试在轻链和重链可变区定位互补决定残基。
Ann N Y Acad Sci. 1971 Dec 31;190:382-93. doi: 10.1111/j.1749-6632.1971.tb13550.x.
10
Localization of two additional hypervariable regions in immunoglobulin heavy chains.免疫球蛋白重链中另外两个高变区的定位
Proc Natl Acad Sci U S A. 1971 Sep;68(9):2019-21. doi: 10.1073/pnas.68.9.2019.

具有抗半抗原活性的小鼠骨髓瘤蛋白重链（α链）可变区的氨基酸序列。

Amino-acid sequence of the variable region of the heavy (alpha) chain of a mouse myeloma protein with anti-hapten activity.

作者信息

Francis S H, Leslie R G, Hood L, Eisen H N

出版信息

Proc Natl Acad Sci U S A. 1974 Apr;71(4):1123-7. doi: 10.1073/pnas.71.4.1123.

DOI:10.1073/pnas.71.4.1123
PMID:4524622
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC388175/
Abstract

Cyanogen bromide cleavage of the heavy (alpha) chain of protein 315 (an immunoglobulin A mouse myeloma protein with anti-dinitrophenyl activity) yielded five fragments of which one (CN2), with 156 residues, contained the chain's entire variable region. Determination of the amino-acid sequence of CN2 showed that: (1) the variable region has appreciable homology (about 33% identities) with the variable region of the light chain from the same molecule; and (2) the constant-region sequence immediately following the probable transition from variable to constant domains is the same in the protein-315 alpha as in human gamma1 and mu chains (-Val-Ser-Ser-). The sequence of the cyanogen bromide octapeptide (CN5) from the carboxy terminus of the protein-315 heavy chain closely resembles the corresponding segments of human alpha and mu chains.

摘要

对蛋白315（一种具有抗二硝基苯基活性的免疫球蛋白A小鼠骨髓瘤蛋白）的重（α）链进行溴化氰裂解，产生了五个片段，其中一个片段（CN2）有156个残基，包含该链的整个可变区。对CN2氨基酸序列的测定表明：（1）该可变区与同一分子轻链的可变区具有明显的同源性（约33%的同一性）；（2）在可能从可变结构域向恒定结构域转变之后紧接着的恒定区序列，在蛋白315α链中与人γ1和μ链中的相同（-Val-Ser-Ser-）。来自蛋白315重链羧基末端的溴化氰八肽（CN5）的序列与人类α链和μ链的相应片段非常相似。