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免疫球蛋白γ1链基因重排及重链类别转换机制

Rearrangement of immunoglobulin gamma 1-chain gene and mechanism for heavy-chain class switch.

作者信息

Kataoka T, Kawakami T, Takahashi N, Honjo T

出版信息

Proc Natl Acad Sci U S A. 1980 Feb;77(2):919-23. doi: 10.1073/pnas.77.2.919.

DOI:10.1073/pnas.77.2.919
PMID:6767246
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC348393/
Abstract

Cloning and nucleotide sequence determination suggest that the rearranged gamma 1-chain gene in a gamma 1-chain-producing myeloma a-pears to be formed by the recombination between the 5' flanking regions of the gamma 1- and mu-chain genes of undifferentiated cells. The recombination site is distinct from the putative J region and is a novel region that we call the S region. We have extended our previous model that explains the heavy-chain class switching by two or more successive recombination events.

摘要

克隆和核苷酸序列测定表明，在产生γ1链的骨髓瘤中重排的γ1链基因似乎是由未分化细胞的γ1链和μ链基因的5'侧翼区域之间的重组形成的。重组位点与假定的J区域不同，是一个我们称为S区域的新区域。我们扩展了之前的模型，该模型通过两个或更多连续的重组事件来解释重链类别转换。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/1247800e246b/pnas00665-0237-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/9ad1d8c0dd36/pnas00665-0235-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/b71fe8042b0e/pnas00665-0237-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/43c0906a5b7d/pnas00665-0237-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/1247800e246b/pnas00665-0237-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/9ad1d8c0dd36/pnas00665-0235-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/b71fe8042b0e/pnas00665-0237-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/43c0906a5b7d/pnas00665-0237-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7978/348393/1247800e246b/pnas00665-0237-c.jpg

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本文引用的文献

1
Improved separation of transfer RNA's on polychlorotrifuoroethylene-supported reversed-phase chromatography columns.在聚氯三氟乙烯支持的反相色谱柱上改进转运RNA的分离。
Biochim Biophys Acta. 1971 Feb 11;228(3):770-4. doi: 10.1016/0005-2787(71)90748-9.
2
Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.大肠杆菌中的超螺旋环状DNA-蛋白质复合物：纯化及诱导转化为开放环状DNA形式
Proc Natl Acad Sci U S A. 1969 Apr;62(4):1159-66. doi: 10.1073/pnas.62.4.1159.
3
Organization of immunoglobulin genes: reiteration frequency of the mouse kappa chain constant region gene.
Mol Biotechnol. 2018 Jun;60(6):435-453. doi: 10.1007/s12033-018-0081-8.
4
Precise and in situ genetic humanization of 6 Mb of mouse immunoglobulin genes.精确且原位遗传人源化 6Mb 大小的小鼠免疫球蛋白基因。
Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5147-52. doi: 10.1073/pnas.1323896111. Epub 2014 Mar 25.
5
Genome complexity in the coelacanth is reflected in its adaptive immune system.腔棘鱼的基因组复杂性在其适应性免疫系统中得以体现。
J Exp Zool B Mol Dev Evol. 2014 Sep;322(6):438-63. doi: 10.1002/jez.b.22558. Epub 2014 Jan 24.
6
Regulation of AID, the B-cell genome mutator.调控 AID，B 细胞基因组的突变酶。
Genes Dev. 2013 Jan 1;27(1):1-17. doi: 10.1101/gad.200014.112.
7
Promising personalized therapeutic options for diffuse large B-cell Lymphoma Subtypes with oncogene addictions.具有致癌基因成瘾的弥漫性大 B 细胞淋巴瘤亚型的有前景的个性化治疗选择。
Clin Cancer Res. 2012 Sep 1;18(17):4538-48. doi: 10.1158/1078-0432.CCR-12-0217. Epub 2012 Jun 27.
8
AID from bony fish catalyzes class switch recombination.硬骨鱼的激活诱导脱氨酶催化类别转换重组。
J Exp Med. 2005 Sep 19;202(6):733-8. doi: 10.1084/jem.20051378. Epub 2005 Sep 12.
9
Simultaneous expression of mu- and gamma-chain mRNA in cloned murine B-lymphoma cell lines.克隆的小鼠B淋巴瘤细胞系中μ链和γ链mRNA的同时表达。
EMBO J. 1983;2(2):167-72. doi: 10.1002/j.1460-2075.1983.tb01400.x.
10
Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination.重组连接末端的可变缺失和重复：对类别转换重组中交错双链切割的影响
Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13860-5. doi: 10.1073/pnas.241524898.
免疫球蛋白基因的组织：小鼠κ链恒定区基因的重复频率
Proc Natl Acad Sci U S A. 1974 Sep;71(9):3659-63. doi: 10.1073/pnas.71.9.3659.
4
Mouse immunoglobulin heavy chains are coded by multiple germ line variable region genes.小鼠免疫球蛋白重链由多个种系可变区基因编码。
Proc Natl Acad Sci U S A. 1974 Oct;71(10):4096-100. doi: 10.1073/pnas.71.10.4096.
5
The molecular basis of antibody formation: a paradox.抗体形成的分子基础：一个悖论。
Proc Natl Acad Sci U S A. 1965 Sep;54(3):864-9. doi: 10.1073/pnas.54.3.864.
6
Detection of specific sequences among DNA fragments separated by gel electrophoresis.在通过凝胶电泳分离的DNA片段中检测特定序列。
J Mol Biol. 1975 Nov 5;98(3):503-17. doi: 10.1016/s0022-2836(75)80083-0.
7
Nucleotide sequence of the rightward operator of phage lambda.噬菌体λ右向操纵基因的核苷酸序列。
Proc Natl Acad Sci U S A. 1975 Mar;72(3):1184-8. doi: 10.1073/pnas.72.3.1184.
8
The complete sequence of the murine monoclonal immunoglobulin MOPC 173 (IgG2a): genetic implications.鼠单克隆免疫球蛋白MOPC 173（IgG2a）的完整序列：遗传学意义
Ann Immunol (Paris). 1976 Sep-Oct;127(5):607-31.
9
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Cell. 1977 Oct;12(2):429-39. doi: 10.1016/0092-8674(77)90119-2.
10
A simple method for DNA restriction site mapping.一种用于DNA限制性酶切位点图谱绘制的简单方法。
Nucleic Acids Res. 1976 Sep;3(9):2387-98. doi: 10.1093/nar/3.9.2387.