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替卡西林对铜绿假单胞菌的形态学改变：一项扫描电子显微镜研究。

Morphological alterations of Pseudomonas aeruginosa by ticarcillin: a scanning electron microscope study.

作者信息

Prior R B, Warner J F

出版信息

Antimicrob Agents Chemother. 1974 Dec;6(6):853-5. doi: 10.1128/AAC.6.6.853.

DOI:10.1128/AAC.6.6.853
PMID:4218072
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC444749/
Abstract

Pseudomonas aeruginosa was exposed to 0.1, 1.0, 10, 100, and 1,000 times the minimal inhibitory concentration of ticarcillin in vitro and subsequently examined with the scanning electron microscope. The morphological alterations observed were filamentation, mid-cell defects, and spheroplast formation, and these alterations were dependent upon the drug concentration.

摘要

将铜绿假单胞菌在体外暴露于替卡西林最低抑菌浓度的0.1、1.0、10、100和1000倍浓度下，随后用扫描电子显微镜进行检查。观察到的形态学改变包括丝状化、细胞中部缺陷和原生质球形成，且这些改变取决于药物浓度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/444749/71b121620c27/aac00342-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/444749/71b121620c27/aac00342-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/213f/444749/71b121620c27/aac00342-0196-a.jpg

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本文引用的文献

1
In vitro studies of alpha-carboxyl-3-thienylmethyl penicillin, a new semisynthetic penicillin.新型半合成青霉素α-羧基-3-噻吩甲基青霉素的体外研究
Appl Microbiol. 1971 Jan;21(1):61-5. doi: 10.1128/am.21.1.61-65.1971.
2
Fluid and pharmacological dynamics in a subcutaneous chamber implanted in rats.植入大鼠皮下腔室的流体和药理动力学
Antimicrob Agents Chemother. 1973 Aug;4(2):196-7. doi: 10.1128/AAC.4.2.196.
3
Artifacts induced by preparation for scanning electron microscopy, in Proteus mirabilis exposed to carbenicillin.奇异变形杆菌在暴露于羧苄青霉素后，扫描电子显微镜样本制备过程中产生的伪像。
利用电子显微镜评估抗生素疗效：胍基脲基头孢菌素、氯苯甲酰脲基头孢菌素、BL-P1654和羧苄青霉素对铜绿假单胞菌的形态学影响。
Antimicrob Agents Chemother. 1976 Feb;9(2):334-42. doi: 10.1128/AAC.9.2.334.
Can J Microbiol. 1974 May;20(5):794-5. doi: 10.1139/m74-122.