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神经行为发育的大鼠模型。

A rat model of neurobehavioral development.

作者信息

Lapointe G, Nosal G

出版信息

Experientia. 1979 Feb 15;35(2):205-7. doi: 10.1007/BF01920618.

DOI:10.1007/BF01920618
PMID:421830
Abstract

The neurobehavioral evolution of the normally growing rat has been investigated by means of a series of reflex, motor and sensory tests from birth up to weaning. A sequential development of behavioral responses has been assessed over this 21-days period, and 2nd week following birth representing an important step in the neurobehavioral maturation of the rat. This rat model may be considered as an useful reference to evaluate changes that may be induced by pharmacological and toxicological agents in the developing exposed rat.

摘要

通过一系列从出生到断奶的反射、运动和感觉测试,对正常生长大鼠的神经行为发育进行了研究。在这21天的时间里评估了行为反应的顺序发展,出生后的第二周是大鼠神经行为成熟的重要阶段。该大鼠模型可被视为评估发育中暴露大鼠体内药物和毒理学制剂可能引起的变化的有用参考。

相似文献

1
A rat model of neurobehavioral development.神经行为发育的大鼠模型。
Experientia. 1979 Feb 15;35(2):205-7. doi: 10.1007/BF01920618.
2
Exercise during development induces an increase in Purkinje cell dendritic tree size.发育期间的运动可导致浦肯野细胞树突状树大小增加。
Science. 1979 Oct 12;206(4415):230-2. doi: 10.1126/science.482938.
3
Tri-layer wrinkling as a mechanism for anchoring center initiation in the developing cerebellum.三层褶皱作为发育中小脑中心起始的锚定机制。
Soft Matter. 2016 Jul 7;12(25):5613-20. doi: 10.1039/c6sm00526h. Epub 2016 Jun 2.
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Histogenesis of the cerebellar climbing fiber in the rat.大鼠小脑攀缘纤维的组织发生
J Comp Neurol. 1971 Jul;142(3):377-91. doi: 10.1002/cne.901420307.
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Cerebellar plasticity: modification of Purkinje cell structure by differential rearing in monkeys.小脑可塑性:通过对猴子进行不同饲养方式来改变浦肯野细胞结构
Science. 1979 Oct 12;206(4415):227-9. doi: 10.1126/science.113873.
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Expression of serotonin2A receptors in Purkinje cells of the developing rat cerebellum.发育中大鼠小脑浦肯野细胞中5-羟色胺2A受体的表达。
Neurosci Res. 2004 Dec;50(4):411-7. doi: 10.1016/j.neures.2004.08.010.
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A theory of cerebellar cortex.小脑皮质理论。
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Focal axonal swellings in rat cerebellar Purkinje cells during normal development.正常发育过程中大鼠小脑浦肯野细胞的局灶性轴突肿胀
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Neurotoxicological effects of nicotine on the embryonic development of cerebellar cortex of chick embryo during various stages of incubation.尼古丁对鸡胚孵化不同阶段小脑皮质胚胎发育的神经毒理学效应。
Tissue Cell. 2015 Oct;47(5):506-14. doi: 10.1016/j.tice.2015.07.002. Epub 2015 Jul 13.
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Effects of two levels of gestational-lactational undernutrition on the postweaning growth of the rat cerebellum.孕期-哺乳期两个水平的营养不足对大鼠断奶后小脑生长的影响。
Exp Neurol. 1973 Mar;38(3):420-8. doi: 10.1016/0014-4886(73)90164-7.

引用本文的文献

1
Behavior and monoamine deficits in prenatal and perinatal iron deficiency are not corrected by early postnatal moderate-iron or high-iron diets in rats.产前和围产期铁缺乏症导致的行为和单胺缺陷,不能通过大鼠出生后早期的中、高铁饮食来纠正。
J Nutr. 2012 Nov;142(11):2040-9. doi: 10.3945/jn.112.162198. Epub 2012 Sep 18.
2
The postnatal evolution of muscular twitches in the developing rat.
Experientia. 1979 Aug 15;35(8):1070-2. doi: 10.1007/BF01949947.

本文引用的文献

1
Reflex-ontogeny and behavioural development of the mouse.小鼠的反射个体发生与行为发育
Anim Behav. 1965 Apr-Jul;13(2):234-41. doi: 10.1016/0003-3472(65)90041-2.
2
Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer.大鼠小脑皮质的出生后发育。II. 浦肯野细胞和分子层成熟的阶段。
J Comp Neurol. 1972 Aug;145(4):399-463. doi: 10.1002/cne.901450402.
3
A developmental time scale for postnatal changes in brain and behavior of B6D2F2 mice.
Brain Res. 1974 Jun 7;72(2):251-64. doi: 10.1016/0006-8993(74)90863-4.
4
[Neo and postnatal development of the cerebral cortex in mice. Ultrastructural study].[小鼠大脑皮质的新生及出生后发育。超微结构研究]
Acta Neurol Latinoam. 1975;21(1-4):1-16.
5
Postnatal development of locomotion in the laboratory rat.实验大鼠运动的产后发育
Anim Behav. 1975 Nov;23(4):896-920. doi: 10.1016/0003-3472(75)90114-1.