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辛基胍对非洲爪蟾心脏电活动的影响。

Effects of octylguanidine on the electrical activity of Xenopus heart.

作者信息

Re G G, Meda E

出版信息

Experientia. 1979 Feb 15;35(2):235-6. doi: 10.1007/BF01920636.

DOI:10.1007/BF01920636
PMID:421843
Abstract

The effects of laboratory synthesized octylguanidine are described. There is an early decease of the maximum rate of rise of the action potential with negligible reduction of the overshoot although the membrane resting potential is unchanged. Subsequently, there is a remarkable reduction of both membrane potential and overshoot, while the plateau is shortened. The former effects resemble those seen with tetrodotoxin, the latter ones, with metabolic poisons.

摘要

描述了实验室合成的辛基胍的作用。动作电位最大上升速率早期下降,超射值仅有可忽略不计的降低,尽管膜静息电位未变。随后,膜电位和超射值均显著降低,同时平台期缩短。前者的作用类似于河豚毒素所见的作用,后者的作用类似于代谢毒物所见的作用。

相似文献

1
Effects of octylguanidine on the electrical activity of Xenopus heart.辛基胍对非洲爪蟾心脏电活动的影响。
Experientia. 1979 Feb 15;35(2):235-6. doi: 10.1007/BF01920636.
2
Effects of octylguanidine on the electrical and mechanical events of xenopus heart.
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本文引用的文献

1
Alkylguanidines as inhibitors of k transport in isolated barley roots.烷基胍作为大麦根中钾离子转运抑制剂。
Plant Physiol. 1975 Oct;56(4):460-3. doi: 10.1104/pp.56.4.460.
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The effect of the cardiac membrane potential on the rapid availability of the sodium-carrying system.心脏膜电位对钠转运系统快速可用性的影响。
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The effect of alkylguanidines on mitochondrial metabolism.烷基胍对线粒体代谢的影响。
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Effects of adrenaline on membrane inward currents during the cardiac action potential.肾上腺素对心脏动作电位期间膜内向电流的影响。
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Interaction of biguanides with mitochondrial and synthetic membranes.双胍类药物与线粒体膜及合成膜的相互作用。
Eur J Biochem. 1972 May 23;27(2):364-75. doi: 10.1111/j.1432-1033.1972.tb01846.x.
6
Existence and role of a slow inward current during the frog atrial action potential.蛙心房动作电位期间缓慢内向电流的存在及其作用
Pflugers Arch. 1969;308(2):91-110. doi: 10.1007/BF00587018.
7
Studies with guanidines on the mechanism of K+ transport in yeast.关于胍类对酵母中钾离子转运机制的研究。
FEBS Lett. 1973 Aug 1;34(1):117-9. doi: 10.1016/0014-5793(73)80717-3.
8
Guanidine derivatives in medicine.医学中的胍衍生物。
N Engl J Med. 1973 Jul 19;289(3):141-6. doi: 10.1056/NEJM197307192890308.
9
Membrane current and contraction in frog atrial fibres.青蛙心房纤维中的膜电流与收缩
J Physiol. 1972 Dec;227(1):141-71. doi: 10.1113/jphysiol.1972.sp010024.
10
Respiratory changes induced by guanidines and cations in submitochondrial particles.
Arch Biochem Biophys. 1973 Nov;159(1):520-7. doi: 10.1016/0003-9861(73)90484-0.