Ardelt W, Pasold K, Hillemanns H G
Fortschr Med. 1979 Mar 15;97(10):471-4.
It is reported on the side-effects of the antithrombotic prophylaxis in 10611 gynecological operations and caesarean sections at the University Hospital Freiburg/Br. Because of multiple side-effects a risk-free method of antithrombotic prophylaxis does not exist. The main problem in using heparin and oral anticoagulants are the complications caused by bleeding. Two cumarine necroses were observed. Two severe anaphylactoid reactions were seen under dextran prophylaxis resulting in the death of one newborn. Wound healing is delayed under low-dose heparin due to an increase in hematomas. Additionally two fatal pulmonary embolisms were caused by the so-called "rebound effect" after use of low-dose heparin.
本文报道了弗莱堡大学医院/布赖斯高院区10611例妇科手术和剖宫产术中抗血栓预防的副作用。由于存在多种副作用，不存在无风险的抗血栓预防方法。使用肝素和口服抗凝剂的主要问题是出血引起的并发症。观察到两例香豆素坏死。在使用右旋糖酐预防时出现两例严重类过敏反应，导致一名新生儿死亡。低剂量肝素会因血肿增加而延迟伤口愈合。此外，低剂量肝素使用后出现的所谓“反跳效应”导致两例致命性肺栓塞。
