Konst H, McKercher P D, Gorham P R, Robertson A, Howell J
Can J Comp Med Vet Sci. 1965 Sep;29(9):221-8.
Toxicity tests with lyophilized M. aeruginosa NRC-1 cells have been conducted using mice, guinea pigs, rabbits, chickens, ducks, two calves and one lamb as the test animals. The symptoms and pathological changes are described. On an equivalent weight basis it required three to five times the oral dosage to kill the large animals and birds as it did to kill the laboratory animals. The symptoms were less pronounced and the survival times were longer in the more resistant animals. Enlargement and congestion of the liver with necrosis of the hepatic cells were constant and pathognomonic. These findings are in general agreement with the observations of other workers who have examined the toxicity of naturally occurring Microcystis waterblooms. The toxicities and structures of microcystin and of six other biologically active cyclic polypeptides are summarized. The pathological effects produced by microcystin in laboratory and domestic animals resemble those produced in man but differ from those produced in animals by the toxic peptides of Amanita phalloides.
已使用小鼠、豚鼠、兔子、鸡、鸭、两头小牛和一只小羊作为实验动物，对冻干的铜绿微囊藻NRC - 1细胞进行了毒性测试。描述了症状和病理变化。以同等重量计算，杀死大型动物和鸟类所需的口服剂量是杀死实验动物的三到五倍。在抗性较强的动物中，症状不那么明显，存活时间更长。肝脏肿大、充血以及肝细胞坏死是持续且具有特征性的。这些发现总体上与其他研究天然微囊藻水华毒性的工作者的观察结果一致。总结了微囊藻毒素和其他六种生物活性环肽的毒性和结构。微囊藻毒素在实验动物和家畜中产生的病理效应与在人类中产生的相似，但与毒伞肽在动物中产生的不同。
