Martinez D
Infect Immun. 1979 Jan;23(1):45-8. doi: 10.1128/iai.23.1.45-48.1979.
Susceptibility to induction of immune polioencephalomyelitis (IPE) was found to be controlled by a gene that is closely linked to the H-2 complex. Whereas mice of the AKR (H-2k) strain were susceptible to IPE induction, H-2-congenic mice, AKR.H-2b (H-2b from C57BL/6) and AKR.M (H-2m), were resistant. However, susceptibility to IPE may be under additional control by a gene(s) outside of the H-2 region, since both C57BL/6 (H-2b) mice and congenic B6.H-2k mice (H-2k from AKR) were resistant to IPE induction. F1 hybrid mice derived from AKR (susceptible) and DBA/2 (resistant) mice were susceptible to IPE induction, indicating that susceptibility is dominant in at least one gene, but susceptibility developed at a later age in the hybrid mice than in AKR mice. B6.PL-Ly-2a Ly-3a/Cy, C57BR, C57L, PL, and RF strain mice were resistant to ipe induction. Thus, of the 12 inbred strains tested so far, only two (C58 and AKR) are susceptible to IPE.
人们发现，免疫性脑脊髓灰质炎（IPE）的易感性受一个与H-2复合体紧密连锁的基因控制。AKR（H-2k）品系的小鼠易被诱导出IPE，而H-2同基因小鼠AKR.H-2b（来自C57BL/6的H-2b）和AKR.M（H-2m）则具有抗性。然而，IPE的易感性可能还受H-2区域之外的一个或多个基因的额外调控，因为C57BL/6（H-2b）小鼠和同基因B6.H-2k小鼠（来自AKR的H-2k）都对IPE诱导具有抗性。源自AKR（易感）和DBA/2（抗性）小鼠的F1杂交小鼠易被诱导出IPE，这表明易感性在至少一个基因中占主导，但杂交小鼠出现易感性的年龄比AKR小鼠晚。B6.PL-Ly-2a Ly-3a/Cy、C57BR、C57L、PL和RF品系的小鼠对IPE诱导具有抗性。因此，在目前测试的12个近交系中，只有两个（C58和AKR）对IPE易感。
