Welling P G, Thomsen J H, Shug A L, Tse F L
Int J Clin Pharmacol Biopharm. 1979 Feb;17(2):56-60.
The pharmacokinetics of l-carnitine were studied in adult male patients following intravenous infusion of dl-carnitine hydrochloride-L-Carnitine appears to distribute into a rapidly perfused and then a more slowly perfused body space following administration. The overall apparent distribution volume Vd (ss) is consistent with extracellular body water. Serum levels of l-carnitine, from two different dose levels were adequately described by a two-compartment model. 80% of the administered dose was recovered in 24 hour post dose urine.
在成年男性患者静脉输注盐酸消旋肉碱后，对左旋肉碱的药代动力学进行了研究。给药后，左旋肉碱似乎先分布到快速灌注的身体空间，然后再分布到灌注较慢的身体空间。总体表观分布容积Vd（稳态）与细胞外体液一致。两室模型能充分描述两种不同剂量水平的左旋肉碱血清水平。给药剂量的80%在给药后24小时的尿液中回收。
