Vacek A, Bartonicková A, Tkadlecek L
Cell Tissue Kinet. 1976 Jan;9(1):1-8. doi: 10.1111/j.1365-2184.1976.tb01248.x.
The number and concentration of haemopoietic stem cells in the femoral bone marrow and spleen of Wistar rats of different ages were investigated. Stem cells were assayed by the spleen colony technique in irradiated rat recipients. The ability of the recipient spleen to harvest transplanted tissue as a macroscopic colony was found to be dependent on the recipient's age. Changes with senescence were observed also in the concentration and the size of the stem cell compartment both in the marrow and spleen. No differences were demonstrated in the seeding of transplanted colony-forming units into the spleen of recipients of 1 and 4 months of age. A rats-mice strain difference in the effect of senescence on the haemopoietic stem cells is discussed.
研究了不同年龄Wistar大鼠股骨骨髓和脾脏中造血干细胞的数量和浓度。通过脾集落技术在受辐照的大鼠受体中测定干细胞。发现受体脾脏将移植组织收获为宏观集落的能力取决于受体的年龄。在骨髓和脾脏中，也观察到干细胞区室的浓度和大小随衰老而发生变化。在1月龄和4月龄受体的脾脏中，移植的集落形成单位的植入情况未显示出差异。讨论了衰老对造血干细胞影响方面的大鼠-小鼠品系差异。
