Silini G, Andreozzi U, Pozzi L V
Cell Tissue Kinet. 1976 Jul;9(4):341-50. doi: 10.1111/j.1365-2184.1976.tb01282.x.
The respective role of the spleen or of the bone marrow in the regeneration of the haemopoietic progenitor compartment of heavily-irradiated mice has been investigated. Splenectomy was used to this end in animals injected with exogenous isogenic cells or regenerating from endogenous spleen or marrow cells. Analysis of the data as a function of time shows that the presence of the spleen affects marrow CFU repopulation only at the early post-irradiation stages. The expansion of the marrow progenitor pool proceeds, however, rather independently of the spleen and marrow CFU remain eventually as the main source of haemopoietic cells in the surviving mice. Thus the reaction of the spleen may be envisaged as a fast, important but transient contribution to the overall haemopoietic function of heavily-irradiated animals.
已经研究了脾脏或骨髓在受重度照射小鼠造血祖细胞区室再生中的各自作用。为此，在注射外源性同基因细胞或从内源性脾脏或骨髓细胞再生的动物中进行了脾切除术。作为时间函数的数据分析表明，脾脏的存在仅在照射后早期阶段影响骨髓CFU的重新填充。然而，骨髓祖细胞池的扩增相当独立于脾脏进行，并且骨髓CFU最终仍然是存活小鼠中造血细胞的主要来源。因此，可以设想脾脏的反应是对受重度照射动物整体造血功能的快速、重要但短暂的贡献。
