未感染及5型腺病毒感染的HeLa细胞中天冬氨酸转氨甲酰酶的活性。
Activity of aspartate transcarbamylase in uninfected and type 5 adenovirus-infected HeLa cells.
作者信息
Consigli R A, Ginsberg H S
出版信息
J Bacteriol. 1964 May;87(5):1034-43. doi: 10.1128/jb.87.5.1034-1043.1964.
Abstract
Consigli, Richard A. (University of Pennsylvania, Philadelphia), and Harold S. Ginsberg. Activity of aspartate transcarbamylase in uninfected and type 5 adenovirus-infected HeLa cells. J. Bacteriol. 87:1034-1043. 1964.-A two- to three-fold increase in aspartate transcarbamylase (ATCase) activity was observed in type 5 adenovirus-infected HeLa cells 18 hr after infection. The enhanced enzyme activity was virus-specific and dependent on biosynthesis of deoxyribonucleic acid and protein. When various characteristics as well as the kinetics of the enzymes from uninfected and infected cells were compared, ATCase from adenovirus-infected cells was shown to have an altered pH optimum, greater heat stability, increased maximal velocity, and increased K(m) value for aspartate.
摘要
康西格利，理查德·A.（宾夕法尼亚大学，费城），以及哈罗德·S.金斯伯格。未感染和5型腺病毒感染的海拉细胞中天冬氨酸转氨甲酰酶的活性。《细菌学杂志》87:1034 - 1043。1964年。——在感染5型腺病毒的海拉细胞中，感染18小时后观察到天冬氨酸转氨甲酰酶（ATCase）活性增加了两到三倍。增强的酶活性是病毒特异性的，并且依赖于脱氧核糖核酸和蛋白质的生物合成。当比较未感染和感染细胞中酶的各种特性以及动力学时，发现腺病毒感染细胞中的ATCase具有改变的最适pH值、更高的热稳定性、增加的最大速度以及天冬氨酸的K(m)值增加。
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