核糖核酸生物合成在5型腺病毒增殖中的作用。
Role of ribonucleic acid biosynthesis in multiplication of type 5 adenovirus.
作者信息
Flanagan J F, Ginsberg H S
出版信息
J Bacteriol. 1964 May;87(5):977-87. doi: 10.1128/jb.87.5.977-987.1964.
Abstract
Flanagan, John F. (University of Pennsylvania, Philadelphia), and Harold S. Ginsberg. Role of ribonucleic acid biosynthesis in multiplication of type 5 adenovirus. J. Bacteriol. 87:977-987. 1964.-The requirement for ribonucleic acid (RNA) biosynthesis in the multiplication of type 5 adenovirus was investigated by using radioactive phosphorus to label nucleic acids and two pyrimidine analogues, 6-azauridine and 5-fluorouracil or 5-fluorouridine, to inhibit synthesis of functional RNA. The data indicate that biosynthesis of RNA after infection is essential for production of virus-specific deoxyribonucleic acid, virus antigens, and infectious particles. The onset of essential RNA synthesis occurs 8 to 9 hr after virus infection and prior to the biosynthesis of other known virus-induced macromolecules.
摘要
弗拉纳根，约翰·F.（宾夕法尼亚大学，费城）和哈罗德·S.金斯伯格。核糖核酸生物合成在5型腺病毒增殖中的作用。《细菌学杂志》87:977 - 987。1964年。——通过使用放射性磷标记核酸以及两种嘧啶类似物6 - 氮杂尿苷和5 - 氟尿嘧啶或5 - 氟尿苷来抑制功能性RNA的合成，研究了5型腺病毒增殖过程中对核糖核酸（RNA）生物合成的需求。数据表明，感染后RNA的生物合成对于病毒特异性脱氧核糖核酸、病毒抗原和感染性颗粒的产生至关重要。必需RNA合成的起始发生在病毒感染后8至9小时，且在其他已知的病毒诱导大分子的生物合成之前。
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