Correa W M, Pacheco A C
Can J Comp Med Vet Sci. 1967 Aug;31(8):203-6.
Histoplasmosis naturally occurring in laboratory guinea pigs is described in its clinical, necropsy, histological and mycological aspects.The animals if adult show a chronic disease with progressive emaciation and lameness of the hind legs. The young below three months of age died in 2 to 4 weeks presenting ruffled fur, great dorsal curvature and sometimes closed eyelids and catarrhal conjunctivitis. At necropsy the principal lesions were ulcerative gastritis, hemorrhagic and catarrhal enteritis, enlarged spleen and mesenteric lymph nodes. Sometimes the liver, lungs, mediastinal lymph nodes and other organs showed lesions. Histological and mycological demonstration of the fungus completed the diagnosis and the surviving animals were burned and sanitation measures instituted. Histological evidence of histoplasmosis in a cow's lung from the area from which the grass was obtained for the feeding of the guinea pigs suggests an epidemiological link. Efforts will be made to isolate and demonstrate H. capsulatum in wild animals on the same area.
本文从临床、尸检、组织学和真菌学方面描述了实验豚鼠自然发生的组织胞浆菌病。成年动物表现为慢性疾病，伴有进行性消瘦和后腿跛行。三个月以下的幼崽在2至4周内死亡，表现为被毛蓬乱、背部严重弯曲，有时眼睑闭合和卡他性结膜炎。尸检时主要病变为溃疡性胃炎、出血性和卡他性肠炎、脾脏和肠系膜淋巴结肿大。有时肝脏、肺、纵隔淋巴结和其他器官也会出现病变。真菌的组织学和真菌学证明完成了诊断，存活的动物被焚烧并采取了卫生措施。从用于喂养豚鼠的草料产地的一头奶牛肺部获得的组织胞浆菌病组织学证据表明存在流行病学联系。将努力在同一地区的野生动物中分离和证明荚膜组织胞浆菌。
