水杨酰苯胺类：一类新型的氧化磷酸化解偶联活性物质。
Salicylanilides: a new group of active uncouplers of oxidative phosphorylation.
作者信息
Williamson R L, Metcalf R L
出版信息
Science. 1967 Dec 29;158(3809):1694-5. doi: 10.1126/science.158.3809.1694.
PMID:4228706
Abstract
Investigations using housefly mitochondria revealed several salicylanilide derivatives as the most effective uncoupling agents of oxidative phosphorylation reported so far. Even greater inhibition of the associated P(i)-adenosine triphosphate exchange was shown with these compounds in both housefly and rat-liver mitochondria, and close similarity was observed between the two types of organelles.
摘要
对家蝇线粒体的研究表明，几种水杨酰苯胺衍生物是迄今为止报道的最有效的氧化磷酸化解偶联剂。在这两种化合物作用下，家蝇和大鼠肝脏线粒体中相关的无机磷酸-三磷酸腺苷交换均受到更强抑制，并且在这两种细胞器之间观察到了密切的相似性。
Zotero 插件