Mann J D, Butler A B, Johnson R N, Bass N H
J Neurosurg. 1979 Mar;50(3):343-8. doi: 10.3171/jns.1979.50.3.0343.
Arachnoid villi in the intracranial dural sinuses constitute the principal sites for absorption of proteins and particulates from the cerebrospinal fluid (CSF) system. Although arachnoid villi in the rat are morphologically less complex than those found in other mammals, their resistance to CSF outflow, as assessed by a graded series of contstant flow manometric infusions, is similar to that found in other species. Moreover, inulin and polystyrene beads, when infused into the spinal subarachnoid space of rats, are rapidly cleared from the CSF system into intracranial dural sinuses. Inulin appeared in sinus blood 3 minutes after onset of infusion and reached concentrations 26 times greater than those found in the systemic circulation; particulate matter in the form of 0.5 micrometer polystyrene beads showed similar efflux characteristics. Hence, the CSF system of the rat is functionally similar to that found in other mammalian species, with arachnoid villi constituting a major efflux route for clearance of macromolecular and particulate substances.
颅内硬脑膜窦中的蛛网膜绒毛是脑脊液（CSF）系统中蛋白质和颗粒吸收的主要部位。尽管大鼠的蛛网膜绒毛在形态上不如其他哺乳动物的复杂，但通过一系列分级恒流测压输注评估，其对脑脊液流出的阻力与其他物种相似。此外，当将菊粉和聚苯乙烯珠注入大鼠脊髓蛛网膜下腔时，它们会迅速从脑脊液系统清除到颅内硬脑膜窦中。菊粉在输注开始后3分钟出现在窦血中，其浓度达到全身循环中浓度的26倍；0.5微米聚苯乙烯珠形式的颗粒物质显示出类似的流出特征。因此，大鼠的脑脊液系统在功能上与其他哺乳动物物种的相似，蛛网膜绒毛构成了清除大分子和颗粒物质的主要流出途径。
