Matsuda M, Yoneda S, Handa H, Gotoh H
J Neurosurg. 1979 Apr;50(4):483-8. doi: 10.3171/jns.1979.50.4.0483.
The plateau wave, one of the wave forms observed in patients with increased intracranial pressure, has previously been extensively investigated, but its pathophysiological aspect is as yet unclear. The authors undertook a study of cerebral hemodynamic changes while the plateau waves were observed in five brain-tumor patients. Although the number of cases studied was small, a remarkable decrease in cerebrovascular resistance was seen in all patients during the plateau waves. It is suggested that the plateau waves are caused by a marked cerebral vasodilatation. The present results support the thesis that cerebral blood volume is increased during the plateau waves. The plateau waves are closely related to the intrinsic vasomotor control of cerebral circulation, and can occur as long as cerebral vasodilating ability is maintained, irrespective of the existence of cerebral autoregulation.
高原波是颅内压升高患者观察到的波形之一，此前已进行了广泛研究，但其病理生理学方面尚不清楚。作者对5例脑肿瘤患者在观察到高原波时的脑血流动力学变化进行了研究。虽然研究的病例数较少，但在高原波期间所有患者的脑血管阻力均显著降低。提示高原波是由明显的脑血管扩张引起的。目前的结果支持了高原波期间脑血容量增加的论点。高原波与脑循环的内在血管舒缩控制密切相关，只要脑血管舒张能力得以维持，无论脑自动调节是否存在，高原波都可能发生。
