[关于由胺类生物合成N，N-二甲基苯胺-N-氧化物和N，N-二甲基氨基偶氮苯-N4-氧化物及其与血红蛋白和肝微粒体的反应] - Suppr

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超能文献

[On the biological formation of N,N-dimethylanilin-N-oxide and N,N-dimethylaminoazobenzol-N4-oxide from amines as well as their reactions with hemoglobin and liver microsomes].

作者信息

Uehleke H, Stahn V

出版信息

Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966;255(3):287-300.

PMID:4230293

Abstract

摘要

相似文献

[On the biological formation of N,N-dimethylanilin-N-oxide and N,N-dimethylaminoazobenzol-N4-oxide from amines as well as their reactions with hemoglobin and liver microsomes].[关于由胺类生物合成N，N-二甲基苯胺-N-氧化物和N，N-二甲基氨基偶氮苯-N4-氧化物及其与血红蛋白和肝微粒体的反应]

Naunyn Schmiedebergs Arch Pharmakol Exp Pathol. 1966;255(3):287-300.

[The formation of nitrosobenzene, aniline and hemoglobin in cats and dogs after intravenous injection of N-alkylanilines].[猫和狗静脉注射N-烷基苯胺后亚硝基苯、苯胺和血红蛋白的形成]

Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1960;238:546-56.

The role of cytochrome P-450 in the N-oxidation of individual amines.细胞色素P-450在单个胺类N-氧化中的作用。

Drug Metab Dispos. 1973 Jan-Feb;1(1):299-313.

Reduction of tertiary amine N-oxides by liver microsomal cytochrome P-450.肝脏微粒体细胞色素P-450对叔胺N-氧化物的还原作用。

Mol Pharmacol. 1976 Mar;12(2):322-34.

The failure of some aromatic amines to produce hemiglobin in vivo in spite of microsomal N-hydroxylation.尽管微粒体N-羟基化，但某些芳香胺在体内未能产生高铁血红蛋白。

Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1965 Jun 18;251(2):201-11. doi: 10.1007/BF00420171.

Microsomal flavoprotein-catalyzed N-oxidation of arylamines.

Drug Metab Dispos. 1973 Jan-Feb;1(1):314-21.

Reactions of 4-halogeno-N,N-dimethylaniline-N-oxide with hemoglobin.

Naunyn Schmiedebergs Arch Pharmacol. 1975;291(1):31-45. doi: 10.1007/BF00510819.

Changes in fatty acid and cholesterol synthesis in rat liver slices due to aromatic amines formed during the degradation of some herbicides.

Bull Environ Contam Toxicol. 1979 Apr;21(6):831-6. doi: 10.1007/BF01685513.

The effect of DPPD on the decarboxylation of retinoic acid in vitro and in vivo.

Arch Biochem Biophys. 1969 Jan;129(1):290-5. doi: 10.1016/0003-9861(69)90178-7.

Metabolism of carcinogenic compounds. I. Effect of phenobarbital and methylcholanthrene on the activities of N-demethylation of carcinogenic compounds by liver microsomes of male and female rats.致癌化合物的代谢。I. 苯巴比妥和甲基胆蒽对雄性和雌性大鼠肝微粒体中致癌化合物N-去甲基化活性的影响。

Gan. 1967 Oct;58(5):467-9.

引用本文的文献

[Influence of diethylnitrosamine, carbon tetrachloride, butter yellow and cyclophosphamide on amino acid incorporation into fractions of liver homogenates after metabolic activation in vitro. Possibilities for the detection of hepatotoxic effects].[二乙基亚硝胺、四氯化碳、奶油黄和环磷酰胺对体外代谢活化后氨基酸掺入肝匀浆各组分的影响。检测肝毒性作用的可能性]

Arch Toxikol. 1969;25(2):169-82.

Mechanism of the autocatalytic formation of ferrihemoglobin by N,N-dimethylaniline-N-oxide.N,N-二甲基苯胺-N-氧化物自催化形成高铁血红蛋白的机制。

Naunyn Schmiedebergs Arch Pharmakol. 1971;268(3):247-63. doi: 10.1007/BF00997260.

Biotransformation and some effects of 2-dimethylamino-4-(N-methylanilino)-phenol in dogs.

Naunyn Schmiedebergs Arch Pharmacol. 1977 Jul;298(3):217-22. doi: 10.1007/BF00500890.

本文引用的文献

FORMATION OF AN INTERMEDIATE N-OXIDE IN THE OXIDATIVE DEMETHYIATION OF N,N-DIMETHYIANILINE CATALYZED BY LIVER MICROSOMES.肝脏微粒体催化N,N-二甲基苯胺氧化脱甲基过程中中间产物N-氧化物的形成。

Biochem Biophys Res Commun. 1964 Mar 9;15(2):188-93. doi: 10.1016/0006-291x(64)90322-5.

In vivo combinations between carcinogens and tissue constituents and their possible role in carcinogenesis.致癌物与组织成分在体内的组合及其在致癌过程中的可能作用。

Cancer Res. 1952 Aug;12(8):547-56.

AMINOAZO DYE AMINE-N-OXIDE AS A POSSIBLE INTERMEDIATE METABOLITE PRECEDING N-DEMETHYLATION AND ORTHO-HYDROXYLATION, AS WELL AS AZO DYE-PROTEIN BINDING.氨基偶氮染料胺 - N - 氧化物作为N - 去甲基化和邻位羟基化以及偶氮染料 - 蛋白质结合之前可能的中间代谢产物。

Gan. 1963 Jun;54:195-203.

Oxidative demethylation and carcinogenicity of 4-N-dimethylaminoazobenzene derivatives.

Nature. 1961 Sep 16;191:1198-9. doi: 10.1038/1911198b0.

Biochemical and pharmacological changes in the rat following chronic administration of morphine nalorphine and normorphine.大鼠长期给予吗啡、烯丙吗啡和去甲吗啡后的生化及药理变化。

J Pharmacol Exp Ther. 1959 Feb;125(2):105-10.

Ascorbic acid in aromatic hydroxylation. I. A model system for aromatic hydroxylation.抗坏血酸在芳香族羟基化反应中的作用。I. 芳香族羟基化反应的模型体系。

J Biol Chem. 1954 Jun;208(2):731-9.

The carcinogenic aminoazo dyes.致癌性氨基偶氮染料。

Adv Cancer Res. 1953;1:339-96. doi: 10.1016/s0065-230x(08)60007-x.

[Biological oxidation and reduction of nitrogen of aromatic amino- and nitro derivatives and their effect on the organism].

Fortschr Arzneimittelforsch. 1965;8:195-260.

Mechanisms of chemical carcinogenesis: nature of proximate carcinogens and interactions with macromolecules.化学致癌作用机制：近致癌物的性质及其与大分子的相互作用。

Pharmacol Rev. 1966 Mar;18(1):805-38.

3-methylmercapto-N-methyl-4-aminoazobenzene: an alkaline-degradation product of a labile protein-bound dye in the livers of rats fed N,N-dimethyl-4-aminoazobenzene.3-甲基巯基-N-甲基-4-氨基偶氮苯：在喂食N，N-二甲基-4-氨基偶氮苯的大鼠肝脏中，一种与蛋白质结合的不稳定染料的碱性降解产物。

Biochem Biophys Res Commun. 1965 Sep 8;20(5):560-5. doi: 10.1016/0006-291x(65)90435-3.

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