Epstein M F, Nicholls E, Stubblefield P G
J Pediatr. 1979 Mar;94(3):449-53. doi: 10.1016/s0022-3476(79)80600-9.
The effect of oral beta-sympathomimetic tocolytic therapy on neonatal serum glucose concentrations in the first several hours after delivery was examined in 12 babies. Hypoglycemia was noted in eight babies, and was sustained over at least a 30-minute period in five. The group with sustained hypoglycemia had a higher cord serum insulin concentration, a lower serum glucose nadir, and a more rapid initial rate of serum glucose disappearance than those babies with normoglycemia or transient hypoglycemia. Sustained hypoglycemia was observed in five of six babies delivered within two days of the termination of tocolytic therapy, but was not present in any of six babies delivered five or more days after the end of tocolytic therapy. Speculations as to the interaction between beta-sympathomimetic tocolytic drugs administered to the mother and fetal and neonatal glucose metabolism are made.
对12例婴儿研究了口服β-拟交感神经药物抑制宫缩治疗对产后最初数小时新生儿血清葡萄糖浓度的影响。8例婴儿出现低血糖，其中5例低血糖持续至少30分钟。与血糖正常或短暂低血糖的婴儿相比，持续性低血糖组的脐血血清胰岛素浓度更高，血清葡萄糖最低点更低，血清葡萄糖初始消失速率更快。在宫缩抑制治疗终止后两天内分娩的6例婴儿中有5例出现持续性低血糖，但在宫缩抑制治疗结束后5天或更长时间分娩的6例婴儿中均未出现。文中对给母亲使用的β-拟交感神经宫缩抑制药物与胎儿及新生儿葡萄糖代谢之间的相互作用进行了推测。
