Muramatsu M, Iwahashi M, Takeuchi U
J Pharm Sci. 1979 Feb;68(2):175-7. doi: 10.1002/jps.2600680214.
Thermodynamic properties such as the latent heat of fusion, aqueous solubility, heat of solution, and interchange energy with water were determined for single crystals of progesterone in alpha- and beta-forms. The differences in the properties between the polymorphic crystals arise from a dissimilar mode of molecular packing, rather than of molecular conformation, in the unit cells, as reflected in the IR spectral and X-ray crystallographic results..
测定了α型和β型孕酮单晶的热力学性质，如熔化潜热、水溶性、溶解热以及与水的交换能。多晶型晶体之间性质的差异源于晶胞中分子堆积方式的不同，而非分子构象的不同，红外光谱和X射线晶体学结果也反映了这一点。
