Skinner W A, Rackur G, Uyeno E
J Pharm Sci. 1979 Mar;68(3):330-2. doi: 10.1002/jps.2600680319.
A series of tetrahydro- and hexahydrocannabinol derivatives was prepared in which the substituents at position 9 were varied. These compounds were evaluated in mice for their effects on locomotor acitivty, body temperature, muscle tone, and analgesia. Depression of body temperature and locomotor function was demonstrated by several compounds, but all were devoid of any significant analgesic activity.
制备了一系列9位取代基不同的四氢大麻酚和六氢大麻酚衍生物。对这些化合物在小鼠身上进行了评估，观察它们对运动活性、体温、肌张力和镇痛的影响。几种化合物显示出体温降低和运动功能抑制，但所有化合物均无任何显著的镇痛活性。
