Wilson R S, Martin B R, Dewey W L
J Med Chem. 1979 Jul;22(7):879-82. doi: 10.1021/jm00193a025.
A series of compounds was prepared in which the 11-hydroxyl of 11-hydroxy-delta8-THC, the potent metabolite of delta8-THC, was replaced by a methyl, methyoxy, amino, or acetamido group. All of the compounds tested produced behavioral changes in dogs, but only the methoxy compound has analgesic properties in mice. An isosteric oxime was inactive in mice.
