Wilson R S, May E L, Dewey W L
J Med Chem. 1979 Jul;22(7):886-8. doi: 10.1021/jm00193a027.
A series of 9-hydroxylated cannabinoid-like compounds was prepared and tested for analgesic properties in mice and behavioral properties in dogs. Although the prototype compound, 9-nor-9-hydroxyhexahydrocannabinol, has potent antinociceptive activity in laboratory animals, the new analogues were relatively inactive. All of the compounds produced an alteration of behavior in unanesthetized dogs. Two of the compounds produced cannabinoid-like effects and the other two produced general CNS depression.
制备了一系列9-羟基化大麻素样化合物，并对其在小鼠中的镇痛特性和在犬中的行为特性进行了测试。尽管原型化合物9-去甲-9-羟基六氢大麻酚在实验动物中具有强大的抗伤害感受活性，但新的类似物活性相对较低。所有化合物均使未麻醉犬的行为发生改变。其中两种化合物产生了类似大麻素的作用，另外两种则导致了一般性的中枢神经系统抑制。
