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十一烯酸与托萘酯对足癣真菌的体外活性比较。

Comparison of in vitro activity of undecylenic acid and tolnaftate against athlete's foot fungi.

作者信息

Amsel L P, Cravitz L, VanderWyk R, Zahry S

出版信息

J Pharm Sci. 1979 Mar;68(3):384-5. doi: 10.1002/jps.2600680338.

DOI:10.1002/jps.2600680338
PMID:423138
Abstract

Undecylenic acid and tolnaftate were tested in an in vitro test system to evaluate their relative "killing time" efficacy against Trichophyton mentagrophytes, Trichophyton rubrum, and Epidermophyton floccosum. Commercial products containing these active agents were tested similarly. The pure active agents were equivalent in activity. The commercial product containing undecylenic acid appeared to be more effective against the test organisms than did the product containing tolnaftate.

摘要

对十一烯酸和托萘酯在体外测试系统中进行了测试,以评估它们对须癣毛癣菌、红色毛癣菌和絮状表皮癣菌的相对“杀菌时间”效力。对含有这些活性剂的商业产品进行了类似测试。纯活性剂在活性方面相当。含十一烯酸的商业产品对测试微生物的效果似乎比含托萘酯的产品更好。

相似文献

1
Comparison of in vitro activity of undecylenic acid and tolnaftate against athlete's foot fungi.十一烯酸与托萘酯对足癣真菌的体外活性比较。
J Pharm Sci. 1979 Mar;68(3):384-5. doi: 10.1002/jps.2600680338.
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Sertaconazole nitrate shows fungicidal and fungistatic activities against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum, causative agents of tinea pedis.硝酸舍他康唑对引起足癣的红色毛癣菌、须癣毛癣菌和絮状表皮癣菌具有杀菌和抑菌活性。
Antimicrob Agents Chemother. 2011 Sep;55(9):4420-1. doi: 10.1128/AAC.00219-11. Epub 2011 Jul 11.
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Comparative in vitro & in vivo evaluation of tolciclate, tolnaftate, miconazole, clotrimazole & undecylenic acid against Trichophyton mentagrophytes.
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TOLNAFTATE, A POTENT TOPICAL ANTIFUNGAL AGENT.托萘酯,一种有效的局部抗真菌剂。
Arch Dermatol. 1965 Apr;91:372-6.
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Comparison between undecylenic acid and tolnaftate in the treatment of tinea pedis.
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[The treatment of dermatomycoses with Phebrocon].[使用Phebrocon治疗皮肤真菌病]
Z Haut Geschlechtskr. 1969 Dec 1;44(23):979-90.
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Comparative in vitro and in vivo antifungal activity of tolnaftate and various undecylenates.
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Comparative in vitro and in vivo antifungal activity of tolnaftate and various undecylenates: a rebuttal.托萘酯与多种十一烯酸盐的体外和体内抗真菌活性比较:一篇反驳文章
J Pharm Sci. 1980 Jun;69(6):741-2. doi: 10.1002/jps.2600690639.
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A study of dermatophytes and their in-vitro antifungal sensitivity.皮肤癣菌及其体外抗真菌敏感性研究。
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COMPARATIVE STUDY OF TOLNAFTATE SOLUTION AND COMPOUND UNDECYLENIC ACID OINTMENT N.F. IN THE TREATMENT OF EPIDERMOPHYTOSES.托萘酯溶液与复方十一烯酸软膏(美国国家处方集)治疗表皮癣菌病的对比研究
Curr Ther Res Clin Exp. 1965 Jul;7:401-5.

引用本文的文献

1
An in vitro method of evaluating tolnaftate release from topical powder.一种评估外用粉剂中妥萘酯释放的体外方法。
Pharm Res. 1986 Apr;3(2):88-92. doi: 10.1023/A:1016389319174.
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In vitro and in vivo activities of piritetrate (M-732), a new antidermatophytic thiocarbamate.新型抗皮肤癣菌硫代氨基甲酸盐——吡立替酯(M - 732)的体外和体内活性
Antimicrob Agents Chemother. 1989 Dec;33(12):2118-25. doi: 10.1128/AAC.33.12.2118.