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中性粒细胞溶酶体在组织损伤、炎症及超敏反应中的作用。VI. 中性粒细胞和血小板在全身性凝集过敏反应中的参与情况。

The role of PMN-leucocyte lysosomes in tissue injury, inflammation and hypersensitivity. VI. The participation of the PMN-leucocyte and the blood platelet in systemic aggregate anaphylaxis.

作者信息

Movat H Z, Uriuhara T, Taichman N S, Rowsell H C, Mustard J F

出版信息

Immunology. 1968 May;14(5):637-48.

PMID:4231971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1409413/
Abstract

Anaphylaxis due to intravascular interaction of hyperimmune antibody with antigen was studied in rabbits, swine and rats. Obstruction of the pulmonary vessels by the immune precipitates was found to initiate the process. This is followed by aggregation of PMN-leucocytes and platelets in pulmonary vessels and phagocytosis of the precipitates by these blood elements. During this process degranulation of the cells takes place with release of lysosomal contents. As a concomitant a rise in plasma acid protease and other hydrolases was demonstrated, presumably derived from the degranulating PMN-leucocytes and platelets. Unlike leukopaenic animals, normal ones showed a more marked hypotension, a greater tendency to protracted shock and developed focal and confluent haemorrhagic pulmonary lesions. It is suggested that anaphylaxis due to intravascular antigen—antibody interaction or aggregate anaphylaxis is a systemic or pulmonary Arthus reaction, rather than a `true' anaphylaxis.

摘要

在兔、猪和大鼠中研究了高免疫抗体与抗原在血管内相互作用引起的过敏反应。发现免疫沉淀物阻塞肺血管引发了这一过程。随后肺血管中PMN白细胞和血小板聚集，这些血液成分吞噬沉淀物。在此过程中，细胞发生脱颗粒，释放溶酶体内容物。与此同时，血浆酸性蛋白酶和其他水解酶升高，推测来源于脱颗粒的PMN白细胞和血小板。与白细胞减少的动物不同，正常动物表现出更明显的低血压、更易发生持续性休克，并且出现局灶性和融合性出血性肺部病变。有人提出，血管内抗原 - 抗体相互作用引起的过敏反应或聚集性过敏反应是一种全身性或肺部的阿瑟斯反应，而不是“真正的”过敏反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/e09bea3ff36d/immunology00400-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/414602420516/immunology00400-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/d84d866fe078/immunology00400-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/6e814268a6ef/immunology00400-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/e09bea3ff36d/immunology00400-0049-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/414602420516/immunology00400-0050-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/d84d866fe078/immunology00400-0051-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/6e814268a6ef/immunology00400-0048-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2473/1409413/e09bea3ff36d/immunology00400-0049-a.jpg

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引用本文的文献

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Agents Actions. 1981 Dec;11(6-7):550-3. doi: 10.1007/BF01978735.
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本文引用的文献

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HISTAMINE RELEASE FROM BLOOD CELLS IN ANAPHYLAXIS IN VITRO.体外过敏反应中血细胞的组胺释放
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In vivo observations of the vascular reactions to large doses of horse serum using the rabbit ear chamber technique.采用兔耳室技术对大剂量马血清的血管反应进行的体内观察。
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The release of histamine and 5-hydroxytryptamine (serotonin) from platelets by antigen-antibody reactions (in vitro).抗原-抗体反应（体外）导致血小板释放组胺和5-羟色胺（血清素）。
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Effect of prostacyclin (PGI2) on immune-complex-induced neutropenia.前列环素（PGI2）对免疫复合物诱导的中性粒细胞减少症的影响。
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5
Neutropenia induced by systemic infusion of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid: correlation with its in vitro effects upon neutrophils.全身输注5,12 - 二羟基 - 6,8,10,14 - 二十碳四烯酸诱导的中性粒细胞减少症：与其对中性粒细胞的体外效应的相关性
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Lung injury induced by antibody fragments to angiotensin-converting enzyme.
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Heterophile antibodies and tissue injury. 3. A role for platelets in the development of lethal vascular injury during Forssman shock in guinea pigs.嗜异性抗体与组织损伤。3. 血小板在豚鼠福斯曼休克致死性血管损伤发展中的作用。
Am J Pathol. 1973 Aug;72(2):179-200.
8
A study of allograft kidney rejection occurring simultaneously in whole organ and ear chamber grafts in the rabbit.一项关于兔全器官移植和耳腔移植中同时发生同种异体肾排斥反应的研究。
J Exp Med. 1973 Mar 1;137(3):776-98. doi: 10.1084/jem.137.3.776.
9
Heterophile antibodies and tissue injury. 1. Ultrastructure of pulmonary vascular lesions produced by Forssman antiserum in guinea-pigs.嗜异性抗体与组织损伤。1. 福斯曼抗血清在豚鼠中引起的肺血管病变的超微结构
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10
Regulation of lysosomal enzyme secretion: role in inflammation.溶酶体酶分泌的调节：在炎症中的作用
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J Physiol. 1955 Apr 28;128(1):9-27. doi: 10.1113/jphysiol.1955.sp005289.
4
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Life Sci (1962). 1964 Dec;3:1505-12. doi: 10.1016/0024-3205(64)90097-9.
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Life Sci (1962). 1964 Sep;3:1025-32. doi: 10.1016/0024-3205(64)90115-8.
6
ALLERGIC INFLAMMATION. III. THE FINE STRUCTURE OF COLLAGEN FIBRILS AT SITES OF ANTIGEN-ANTIBODY INTERACTION IN ARTHUS-TYPE LESIONS.变应性炎症。III. 阿瑟斯型病变中抗原-抗体相互作用部位胶原纤维的精细结构。
J Exp Med. 1963 Oct 1;118(4):557-64. doi: 10.1084/jem.118.4.557.
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Bull Johns Hopkins Hosp. 1957 Nov;101(5):258-80.