Taichman N S, Creighton M, Stephenson A, Tsai C C
Immunology. 1972 Jan;22(1):93-102.
The ultrastructural features of pulmonary vascular lesions were studied in guinea-pigs subjected to lethal Forssman shock. Within moments after an intravenous injection of Forssman antiserum the endothelia of venules and capillaries exhibited a wide range of morphological changes. Relatively mild lesions were characterized by the appearance of focal erosions in the cell membrane, cytoplasmic swelling and vacuolization. Severe lesions were associated with overt necrosis and disintegration of the endothelial lining, leaving the basement membrane in direct communication with the intravascular compartment. Platelets and PMN-leucocytes were consistently found to be adhering to denuded or damaged vascular surfaces and forming thromboembolic obstructions within blood channels. These data support the concept that vascular endothelium is a primary target tissue in Forssman shock. In addition, our findings suggest that platelets and PMN-leucocytes may be pathogenetic determinants in the development of Forssman shock.
对遭受致死性福斯曼休克的豚鼠的肺血管病变的超微结构特征进行了研究。静脉注射福斯曼抗血清后不久，小静脉和毛细血管的内皮细胞呈现出广泛的形态学变化。相对较轻的病变表现为细胞膜出现局灶性糜烂、细胞质肿胀和空泡化。严重病变则与内皮衬里的明显坏死和崩解有关，使基底膜与血管内腔直接相通。始终发现血小板和PMN白细胞粘附于裸露或受损的血管表面，并在血道内形成血栓栓塞性阻塞。这些数据支持血管内皮是福斯曼休克中的主要靶组织这一概念。此外，我们的研究结果表明，血小板和PMN白细胞可能是福斯曼休克发展中的致病决定因素。
