Elguindi A S, Harrison G N, Abdulla A M, Chaudhary B A, Vallner J J, Kolbeck R C, Speir W A
J Thorac Cardiovasc Surg. 1979 Apr;77(4):557-61.
Twenty-six patients undergoing transnasal fiberoptic bronchoscopy (FOB) were electrocardiographically monitored for 12 hours before, during, and 12 hours after bronchoscopy. We measured arterial lidocaine concentrations during the procedure as well as arterial blood gases before and after the procedure. The incidence of total arrhythmias, including sinus tachycardia, during the control period was 69 percent; minor arrhythmias, 69 percent; and major arrhythmias, 8 percent. During FOB, the incidence of total and minor arrhythmias increased to 77 and 73 percent, respectively; however, the incidence of major arrhythmias decreased to 4 percent. Arterial lidocaine concentrations ranged widely, from 0.1 to 8.7 microgram per milliliter with a mean peak level of 5.0 +/- 0.6 microgram per milliliter, which was reached between 5 and 30 minutes after the insertion of the bronchoscope. We conclude that the incidence of cardiac arrhythmias, excluding sinus tachycardia, during FOB is low and that lidocaine anesthesia probably exerts a protective effect against the development of major arrhythmias during the procedure.
对26例接受经鼻纤维支气管镜检查(FOB)的患者在支气管镜检查前、检查期间及检查后12小时进行心电图监测。我们在检查过程中测量动脉利多卡因浓度以及检查前后的动脉血气。在对照期,包括窦性心动过速在内的总心律失常发生率为69%;轻微心律失常发生率为69%;严重心律失常发生率为8%。在纤维支气管镜检查期间,总心律失常和轻微心律失常的发生率分别增至77%和73%;然而,严重心律失常的发生率降至4%。动脉利多卡因浓度范围广泛,从0.1至8.7微克/毫升,平均峰值水平为5.0±0.6微克/毫升,在插入支气管镜后5至30分钟达到该峰值。我们得出结论,纤维支气管镜检查期间,排除窦性心动过速外,心律失常的发生率较低,并且利多卡因麻醉可能对检查过程中严重心律失常的发生起到保护作用。