Boye N P, Bredesen J E
Scand J Respir Dis. 1979 Jun;60(3):105-8.
The plasma concentration of lidocaine and its metabolite, mono-ethyl-glycine-xylidine, was measured furing fiberoptic bronchoscopy (FB) using an ultrasonic nebulizer to achieve topical anaesthesia. Most patients received additional anaesthesia of the laryngeal region and the tracheobronchial tree during the procedure. The achieved plasma concentrations showed that a substantial amount of lidocaine was absorbed, but toxic plasma levels were not reached. Lidocaine plasma concentration above the therapeutic range for treating cardiac diseases was observed in one patient. The use of an ultrasonic nebulizer with lidocaine before FB seems to give sufficient local anaesthesia and to be a safe method.
在纤维支气管镜检查（FB）期间，使用超声雾化器进行局部麻醉，测定利多卡因及其代谢物单乙基甘氨酸二甲苯二胺的血浆浓度。大多数患者在手术过程中接受了喉部区域和气管支气管树的额外麻醉。所达到的血浆浓度表明，大量利多卡因被吸收，但未达到中毒血浆水平。在一名患者中观察到利多卡因血浆浓度高于治疗心脏病的治疗范围。在FB前使用利多卡因超声雾化器似乎能提供足够的局部麻醉，且是一种安全的方法。
