哇巴因和α-当归内酯对犬心肌微粒体钙代谢的影响。
The influence of ouabain and alpha angelica lactone on calcium metabolism of dog cardiac microsomes.
作者信息
Entman M L, Cook J W, Bressler R
出版信息
J Clin Invest. 1969 Feb;48(2):229-34. doi: 10.1172/JCI105979.
The influence of ouabain and alpha angelica lactone on (45)calcium accumulation in cardiac microsomes was studied. Calcium binding (accumulation in the absence of excess oxalate or phosphate) was augmented by both ouabain and alpha angelica lactone in the presence of adenosine triphosphate (ATP) but unaffected in its absence. Calcium turnover (defined as the change in (45)Ca(++) bound to the microsomes after the specific activity is changed) was studied to determine if the augmented bound pool was freely exchangeable at equilibrium. Ouabain and alpha angelica lactone augmented calcium turnover in both the presence and absence of ATP. Calcium-stimulated ATPase was increased by both agents.It is proposed that these two unsaturated lactones, with known cardiotonic activity, may exert their effects by providing an increased contraction-dependent calcium pool to be released upon systolic depolarization.
研究了哇巴因和α-当归内酯对心脏微粒体中（45）钙积累的影响。在存在三磷酸腺苷（ATP）的情况下，哇巴因和α-当归内酯均可增强钙结合（在没有过量草酸盐或磷酸盐的情况下积累），但在不存在ATP时则无影响。研究了钙周转（定义为比活性改变后与微粒体结合的（45）Ca（++）的变化），以确定增加的结合池在平衡时是否可自由交换。无论有无ATP，哇巴因和α-当归内酯均可增强钙周转。两种药物均可增加钙刺激的ATP酶活性。有人提出，这两种具有已知强心活性的不饱和内酯可能通过提供增加的收缩依赖性钙池来发挥作用，该钙池在收缩期去极化时释放。
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