• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

大脑中的神经酰胺代谢

Ceramide metabolism in brain.

作者信息

Kishimoto Y, Kawamura N

出版信息

Mol Cell Biochem. 1979 Jan 15;23(1):17-25. doi: 10.1007/BF00226676.

DOI:10.1007/BF00226676
PMID:423891
Abstract

Ceramide is the fundamental structure and key intermediate of all sphingolipids. Biosynthesis and catabolism of brain ceramide, especially their relationship to the metabolism of more complex sphingolipids in brain, are reviewed. Human genetic diseases which involve altered ceramide metabolism are also discussed.

摘要

神经酰胺是所有鞘脂的基本结构和关键中间体。本文综述了脑内神经酰胺的生物合成与分解代谢,尤其是它们与脑内更复杂鞘脂代谢的关系。文中还讨论了涉及神经酰胺代谢改变的人类遗传疾病。

相似文献

1
Ceramide metabolism in brain.大脑中的神经酰胺代谢
Mol Cell Biochem. 1979 Jan 15;23(1):17-25. doi: 10.1007/BF00226676.
2
[Biochemical aspects of sphingolipidosis].[鞘脂贮积症的生化方面]
Ann Biol Clin (Paris). 1972;30(6):623-35.
3
Biosynthesis and metabolic degradation of sphingolipids not containing sialic acid.不含唾液酸的鞘脂的生物合成与代谢降解
J Lipid Res. 1972 May;13(3):293-310.
4
2n-fatty acids from phosphatidylcholine label sphingolipids--a novel role of phospholipase A2?来自磷脂酰胆碱的2n-脂肪酸标记鞘脂——磷脂酶A2的新作用?
Biochim Biophys Acta. 2005 Jun 15;1735(1):68-78. doi: 10.1016/j.bbalip.2005.04.008.
5
In vivo metabolism of ceramides in rat brain. Fatty acid replacement and esterification of ceramide.
J Biol Chem. 1977 Oct 25;252(20):7068-73.
6
Glycosphingolipids in cultured human skin fibroblasts. II. Characterization and metabolism in fibroblasts from patients with inborn errors of glycosphingolipid and mucopolysaccharide metabolism.培养的人皮肤成纤维细胞中的糖鞘脂。II. 糖鞘脂和粘多糖代谢先天性缺陷患者成纤维细胞中的特性与代谢
J Biol Chem. 1972 Sep 25;247(18):5951-8.
7
Effect of high fat diet enriched with unsaturated and diet rich in saturated fatty acids on sphingolipid metabolism in rat skeletal muscle.高脂肪饮食(富含不饱和脂肪酸)和富含饱和脂肪酸的饮食对大鼠骨骼肌鞘脂代谢的影响。
J Cell Physiol. 2010 Nov;225(3):786-91. doi: 10.1002/jcp.22283.
8
Sphingolipids of transplantable rat nephroma-RA.可移植大鼠肾瘤 - RA的鞘脂类
Biochemistry (Mosc). 2000 Jun;65(6):703-6.
9
Development of an acid ceramidase activity-based probe.基于酸性神经酰胺酶活性的探针的开发。
Chem Commun (Camb). 2015 Apr 11;51(28):6161-3. doi: 10.1039/c5cc00356c.
10
Functions of sphingolipid metabolism in mammals--lessons from genetic defects.鞘脂代谢在哺乳动物中的功能——来自基因缺陷的启示
Biochim Biophys Acta. 2008 Apr;1781(4):145-83. doi: 10.1016/j.bbalip.2008.01.004. Epub 2008 Feb 2.

引用本文的文献

1
Emerging evidence for the modulation of exocytosis by signalling lipids.信号脂质对胞吐作用的调节作用的新证据。
FEBS Lett. 2018 Nov;592(21):3493-3503. doi: 10.1002/1873-3468.13178. Epub 2018 Jul 10.
2
Sphingolipid metabolism in cultured fibroblasts: microscopic and biochemical studies employing a fluorescent ceramide analogue.培养的成纤维细胞中的鞘脂代谢:使用荧光神经酰胺类似物的显微镜和生化研究。
Proc Natl Acad Sci U S A. 1983 May;80(9):2608-12. doi: 10.1073/pnas.80.9.2608.
3
In vivo metabolism of fluorescent ceramide in central nervous system myelin of adult rats.

本文引用的文献

1
IN VIVO CONVERSIONS OF CEREBROSIDE AND CERAMIDE IN RAT BRAIN.大鼠脑中脑苷脂和神经酰胺的体内转化
J Lipid Res. 1965 Jan;6:140-5.
2
OBSERVATIONS ON CEREBROSIDE METABOLISM IN VIVO.体内脑苷脂代谢的观察
J Biol Chem. 1965 Feb;240:609-12.
3
THE ISOLATION OF BEEF SPHINGOMYELINS.牛肉鞘磷脂的分离
成年大鼠中枢神经系统髓鞘中荧光神经酰胺的体内代谢
Neurochem Res. 1991 May;16(5):551-4. doi: 10.1007/BF00974873.
Can J Biochem. 1964 Dec;42:1659-75. doi: 10.1139/o64-178.
4
STRUCTURES OF THE 2-HYDROXY UNSATURATED FATTY ACIDS OF PIG BRAIN SPHINGOLIPIDS.猪脑鞘脂类2-羟基不饱和脂肪酸的结构
J Lipid Res. 1964 Jan;5:94-7.
5
LIPID COMPONENTS OF GANGLIOSIDES.神经节苷脂的脂质成分
J Lipid Res. 1964 Jan;5:103-8.
6
STRUCTURES OF THE NORMAL UNSATURATED FATTY ACIDS OF BRAIN SPHINGOLIPIDS.脑鞘脂类正常不饱和脂肪酸的结构
J Lipid Res. 1963 Oct;4:437-43.
7
CHROMATOGRAPHIC SEPARATION OF HUMAN BRAIN GANGLIOSIDES.人脑海藻糖神经节苷脂的色谱分离
J Neurochem. 1963 Sep;10:613-23. doi: 10.1111/j.1471-4159.1963.tb08933.x.
8
Enzymatic hydrolysis of sphingolipids. I. Hydrolysis and synthesis of ceramides by an enzyme from rat brain.鞘脂的酶促水解。I. 大鼠脑源性酶对神经酰胺的水解与合成
J Biol Chem. 1966 Aug 25;241(16):3724-30.
9
Changes in sphingosine and fatty acid components of the gangliosides in developing rat and human brain.
J Lipid Res. 1966 Jan;7(1):122-31.
10
Enzymatic hydrolysis of sphingolipids. 8. Further purification and properties of rat brain ceramidase.鞘脂的酶促水解。8. 大鼠脑酰胺酶的进一步纯化及性质
Biochemistry. 1969 Apr;8(4):1692-8. doi: 10.1021/bi00832a052.